Neurobiological Considerations for Tobacco Use Disorder.

IF 2.1 Q3 NEUROSCIENCES Current Behavioral Neuroscience Reports Pub Date : 2018-12-01 Epub Date: 2018-10-30 DOI:10.1007/s40473-018-0168-3

Megha Chawla, Kathleen A Garrison

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引用次数: 5

Abstract

Purpose of review: Neurobiological studies of tobacco/nicotine use examining genetic, molecular, functional, and behavioral correlates have improved our understanding of nicotine/tobacco dependence and have informed treatment. Recent work extending previously established findings and reporting novel methodologies and discoveries in preclinical and human studies are reviewed.

Recent findings: Recent work in preclinical models has focused on the differential roles of nicotinic receptor subtypes and nicotine's effects on neural systems beyond cortico-striatal dopaminergic pathways, and utilizing advanced methodologies such as pharmacogenetics, optogenetics and rodent fMRI to identify targets for treatment. Likewise, human neuroimaging studies have identified molecular and functional dynamic shifts associated with tobacco/nicotine use that further inform treatment.

Summary: Nicotine/tobacco use is associated with widespread neural adaptations that are persistent and function to maintain addiction. The continued identification of genetic, molecular, neural, and behavioral endophenotypes related to nicotine/tobacco use, dependence, and addiction will facilitate the development and delivery of personalized treatment.

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烟草使用障碍的神经生物学因素。

综述目的：对烟草/尼古丁使用的神经生物学研究检查了基因、分子、功能和行为相关性，提高了我们对尼古丁/烟草依赖的理解，并提供了知情的治疗方法。综述了最近在临床前和人体研究中扩展先前确定的发现并报告新方法和发现的工作。最近的发现：最近在临床前模型中的工作集中在烟碱受体亚型的差异作用和尼古丁对皮质-纹状体多巴胺能通路以外的神经系统的影响，并利用药物遗传学、光遗传学和啮齿动物功能磁共振成像等先进方法来确定治疗靶点。同样，人类神经影像学研究已经确定了与烟草/尼古丁使用相关的分子和功能动态变化，这进一步为治疗提供了信息。摘要：尼古丁/烟草的使用与广泛的神经适应有关，这些神经适应是持久的，具有维持成瘾的功能。持续识别与尼古丁/烟草使用、依赖和成瘾相关的遗传、分子、神经和行为内表型将有助于开发和提供个性化治疗。

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来源期刊

Current Behavioral Neuroscience Reports Medicine-Public Health, Environmental and Occupational Health

CiteScore

3.60

自引率

0.00%

发文量

期刊介绍： Under the leadership of Emil Coccaro, Current Behavioral Neuroscience Reports will provide an in-depth review of topics covering personality and impulse control disorders, psychosis, mood and anxiety disorders, genetics and neuroscience, geropsychiatry and cognitive disorders of late life, child and developmental psychiatry, addictions, and neuromodulation.We accomplish this aim by inviting international authorities to contribute review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. By providing clear, insightful balanced contributions, the journal intends to serve those involved in the field of behavioral neuroscience.