HPV and skin carcinogenesis

Massimo Tommasino
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引用次数: 47

Abstract

Epidemiological and biological studies provide several lines of evidence for the involvement of cutaneous beta human papillomaviruses (HPVs), together with ultraviolet (UV) radiation, in the development of cutaneous squamous cell carcinoma. These viruses appear to act with a hit-and-run mechanism, being necessary at an early stage of carcinogenesis and being dispensable for the maintenance of the malignant phenotype. Studies in experimental models show that beta HPVs, mainly via the E6 and E7 oncoproteins, are able to promote proliferation and to circumvent cellular stresses induced by UV radiation. These findings support a model of skin carcinogenesis in which beta HPV-infected keratinocytes remain alive despite the accumulation of UV-induced DNA mutations. In this manner, these cells become highly susceptible to progression towards malignancy. Thus, UV radiation is the main driver of skin cancer development, while beta HPVs act as facilitators of the accumulation of UV-induced DNA mutations.

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HPV和皮肤癌
流行病学和生物学研究提供了几种证据,证明皮肤β人乳头瘤病毒(hpv)与紫外线(UV)辐射参与皮肤鳞状细胞癌的发展。这些病毒似乎以一种“打了就跑”的机制起作用,在癌变的早期阶段是必要的,对于恶性表型的维持是可有可无的。实验模型研究表明,主要通过E6和E7癌蛋白,β - hpv能够促进增殖并规避紫外线辐射诱导的细胞应激。这些发现支持了一种皮肤癌发生的模型,即尽管紫外线诱导的DNA突变积累,β - hpv感染的角质形成细胞仍然存活。以这种方式,这些细胞变得高度容易向恶性肿瘤发展。因此,紫外线辐射是皮肤癌发展的主要驱动因素,而β hpv则是紫外线诱导的DNA突变积累的促进因素。
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审稿时长
14 weeks
期刊介绍: The official Journal of the International Papillomavirus Society Papillomavirus Research (PVR), the Journal of HPV and other Small DNA Tumor Viruses publishes innovative papers related to all aspects of papillomaviruses and other small DNA tumor viruses. The official journal of the International Papillomavirus Society, PVR is an open access publication that aims to bring together virologists, immunologists, epidemiologists and clinicians working in the booming field of HPV and animal papillomaviruses, polyomaviruses and other small DNA tumor viruses and their associated diseases, in order to foster and facilitate interdisciplinary communication. The journal welcomes original research articles, reviews, short communications, opinion articles and regional update reports on papillomaviruses and other tumor viruses in the following sections: a. Biology of papillomaviruses and related viruses from life cycle to cancer b. Epidemiology etiology and natural history studies c. Natural and induced immunity including vaccine research d. Intervention studies and strategies including i. Clinical studies and trials ii. HPV treatments iii. HPV vaccination programs iv. Diagnostics and screening e. Infection and disease prevention, modeling studies f. Guidelines and public health recommendations g. HPV Studies in special populations Regional and local studies on these viruses.
期刊最新文献
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