CP Tensor Decomposition with Cannot-Link Intermode Constraints.

Jette Henderson, Bradley A Malin, Joshua C Denny, Abel N Kho, Jimeng Sun, Joydeep Ghosh, Joyce C Ho
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引用次数: 2

Abstract

Tensor factorization is a methodology that is applied in a variety of fields, ranging from climate modeling to medical informatics. A tensor is an n-way array that captures the relationship between n objects. These multiway arrays can be factored to study the underlying bases present in the data. Two challenges arising in tensor factorization are 1) the resulting factors can be noisy and highly overlapping with one another and 2) they may not map to insights within a domain. However, incorporating supervision to increase the number of insightful factors can be costly in terms of the time and domain expertise necessary for gathering labels or domain-specific constraints. To meet these challenges, we introduce CANDECOMP/PARAFAC (CP) tensor factorization with Cannot-Link Intermode Constraints (CP-CLIC), a framework that achieves succinct, diverse, interpretable factors. This is accomplished by gradually learning constraints that are verified with auxiliary information during the decomposition process. We demonstrate CP-CLIC's potential to extract sparse, diverse, and interpretable factors through experiments on simulated data and a real-world application in medical informatics.

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具有不可链接模式间约束的CP张量分解。
张量因子分解是一种应用于从气候建模到医学信息学等多个领域的方法。张量是一个n向数组,用于捕捉n个对象之间的关系。这些多路阵列可以被分解以研究数据中存在的底层基底。张量因子分解中出现的两个挑战是:1)结果因子可能是有噪声的,并且彼此高度重叠;2)它们可能无法映射到域内的见解。然而,就收集标签或特定领域限制所需的时间和领域专业知识而言,纳入监督以增加有洞察力的因素的数量可能代价高昂。为了应对这些挑战,我们引入了具有不可链接模式间约束的CANDECOMP/PARAFAC(CP)张量分解(CP-CLIC),这是一个实现简洁、多样、可解释因素的框架。这是通过逐步学习在分解过程中用辅助信息验证的约束来实现的。我们通过对模拟数据的实验和在医学信息学中的实际应用,展示了CP-CLIC提取稀疏、多样和可解释因素的潜力。
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FAME: Fragment-based Conditional Molecular Generation for Phenotypic Drug Discovery. Harmonic Alignment. GRIA: Graphical Regularization for Integrative Analysis. CP Tensor Decomposition with Cannot-Link Intermode Constraints. Region-Based Active Learning with Hierarchical and Adaptive Region Construction.
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