{"title":"Radionuclide Imaging of Atherothrombotic Diseases.","authors":"Mitchel R Stacy","doi":"10.1007/s12410-019-9491-7","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>A variety of approaches and molecular targets have emerged in recent years for radionuclide-based imaging of atherosclerosis and vulnerable plaque using single photon emission computed tomography (SPECT) and positron emission tomography (PET), with numerous methods focused on characterizing the mechanisms underlying plaque progression and rupture. This review highlights the ongoing developments in both the preclinical and clinical environment for radionuclide imaging of atherosclerosis and atherothrombosis.</p><p><strong>Recent findings: </strong>Numerous physiological processes responsible for the evolution of high-risk atherosclerotic plaque, such as inflammation, thrombosis, angiogenesis, and microcalcification, have been shown to be feasible targets for SPECT and PET imaging. For each physiological process, specific molecular markers have been identified that allow for sensitive non-invasive detection and characterization of atherosclerotic plaque.</p><p><strong>Summary: </strong>The capabilities of SPECT and PET imaging continue to evolve for physiological evaluation of atherosclerosis. This review summarizes the latest developments related to radionuclide imaging of atherothrombotic diseases.</p>","PeriodicalId":51842,"journal":{"name":"Current Cardiovascular Imaging Reports","volume":null,"pages":null},"PeriodicalIF":0.6000,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12410-019-9491-7","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Cardiovascular Imaging Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12410-019-9491-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2019/3/27 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 7
Abstract
Purpose of review: A variety of approaches and molecular targets have emerged in recent years for radionuclide-based imaging of atherosclerosis and vulnerable plaque using single photon emission computed tomography (SPECT) and positron emission tomography (PET), with numerous methods focused on characterizing the mechanisms underlying plaque progression and rupture. This review highlights the ongoing developments in both the preclinical and clinical environment for radionuclide imaging of atherosclerosis and atherothrombosis.
Recent findings: Numerous physiological processes responsible for the evolution of high-risk atherosclerotic plaque, such as inflammation, thrombosis, angiogenesis, and microcalcification, have been shown to be feasible targets for SPECT and PET imaging. For each physiological process, specific molecular markers have been identified that allow for sensitive non-invasive detection and characterization of atherosclerotic plaque.
Summary: The capabilities of SPECT and PET imaging continue to evolve for physiological evaluation of atherosclerosis. This review summarizes the latest developments related to radionuclide imaging of atherothrombotic diseases.
期刊介绍：
Cardiovascular imaging technologies now play an expanded role in clinical practice. Beyond the diagnosis of a disease process, these techniques are rapidly transitioning to help guide therapy. The journal aims to keep readers current with rapidly evolving advances in instrumentation and imaging procedures that support the expanded role of these technologies in clinical practice. The journal intends to place the entire area of cardiovascular imaging in its proper prospective by establishing the indications and limitations of each imaging technique and by summarizing recent clinical advances.
We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field, including cardiac magnetic resonance, nuclear imaging, echocardiography, cardiac computed tomography, intravascular, molecular, and hybrid imaging. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An Editorial Board of internationally diverse members ensures that topics include emerging research and suggests topics of special interest to their country/region. We also provide commentaries from well-known figures in the field.
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