HPV infections and flat penile lesions of the penis in men who have sex with men

IF 3.2 Papillomavirus Research Pub Date : 2019-12-01 DOI:10.1016/j.pvr.2019.100173

Ward P.H. Van Bilsen , Alexandra Kovaleva , Maaike C.G. Bleeker , Audrey J. King , Sylvia M. Bruisten , Wilma Brokking , Henry J.C. De Vries , Chris J.L.M. Meijer , Maarten F. Schim Van Der Loeff

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引用次数: 5

Abstract

Background

Flat penile lesions (FPL) in heterosexual men are thought to play a role in the transmission of HPV. We investigated the association between FPL and penile HPV, and explored determinants of FPL in men who have sex with men (MSM).

Methods

In 2015–2016, MSM were recruited based on HIV and penile HPV status in a previous cohort. MSM self-completed a questionnaire. Peniscopy was performed after application of acetic acid to visualize FPL. Penile physician-collected samples were tested for HPV-DNA using the highly sensitive SPF10-PCR DEIA/LiPA25 system. HPV viral load (VL) was determined using a quantitative type-specific (q)PCR targeting the L1-region. Presence of HPV and HIV, HPV VL and circumcision status were compared between MSM with and without FPL.

Results

We included 116 MSM, of whom 59/116 (51%) MSM were HIV-positive and 54/116 (47%) had FPL. A penile HPV infection was present in 31/54 (57%) MSM with FPL and 34/62 (55%) MSM without FPL (p = 0.8). There was no difference between MSM with and without FPL regarding presence of penile HPV infection, HPV VL, HIV status or circumcision status (p > 0.05 for all).

Conclusion

Among MSM in Amsterdam, we found no association between FPL and penile HPV, HPV VL, HIV status or circumcision status.

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与男性发生性行为的男性的HPV感染和阴茎扁平病变

背景异性恋男性的阴茎扁平病变(FPL)被认为在HPV的传播中起作用。我们调查了FPL与阴茎HPV之间的关系，并探讨了男男性行为者(MSM) FPL的决定因素。方法2015-2016年，在既往队列中根据HIV和阴茎HPV状况招募MSM。男同性恋者自行完成了一份调查问卷。应用醋酸后进行阴茎镜检查，以观察阴道外泌素。使用高灵敏度的SPF10-PCR DEIA/LiPA25系统检测阴茎医生收集的样本的HPV-DNA。HPV病毒载量(VL)采用定量型特异性(q)PCR靶向l1区确定。比较有和无FPL的MSM的HPV和HIV的存在、HPV VL和包皮环切情况。结果纳入116例MSM，其中59/116(51%)为hiv阳性，54/116(47%)为FPL。阴茎HPV感染在31/54(57%)有FPL的MSM和34/62(55%)无FPL的MSM中存在(p = 0.8)。在阴茎HPV感染、HPV VL、HIV状态或包皮环切情况方面，有和没有FPL的MSM之间没有差异(p > 0.05)。结论在阿姆斯特丹的MSM中，我们发现FPL与阴茎HPV, HPV VL, HIV状态或包皮环切状态无关。

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来源期刊

Papillomavirus Research VIROLOGY-

自引率

0.00%

发文量

审稿时长

14 weeks

期刊介绍： The official Journal of the International Papillomavirus Society Papillomavirus Research (PVR), the Journal of HPV and other Small DNA Tumor Viruses publishes innovative papers related to all aspects of papillomaviruses and other small DNA tumor viruses. The official journal of the International Papillomavirus Society, PVR is an open access publication that aims to bring together virologists, immunologists, epidemiologists and clinicians working in the booming field of HPV and animal papillomaviruses, polyomaviruses and other small DNA tumor viruses and their associated diseases, in order to foster and facilitate interdisciplinary communication. The journal welcomes original research articles, reviews, short communications, opinion articles and regional update reports on papillomaviruses and other tumor viruses in the following sections: a. Biology of papillomaviruses and related viruses from life cycle to cancer b. Epidemiology etiology and natural history studies c. Natural and induced immunity including vaccine research d. Intervention studies and strategies including i. Clinical studies and trials ii. HPV treatments iii. HPV vaccination programs iv. Diagnostics and screening e. Infection and disease prevention, modeling studies f. Guidelines and public health recommendations g. HPV Studies in special populations Regional and local studies on these viruses.