Chemistry and Effects of Brainstem Acting Drugs.

Q3 Psychology Central nervous system agents in medicinal chemistry Pub Date : 2019-01-01 DOI:10.2174/1871524919666190620164355

Saganuwan Alhaji Saganuwan

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引用次数: 4

Abstract

Background: Brain is the most sensitive organ, whereas brainstem is the most important part of Central Nervous System (CNS). It connects the brain and the spinal cord. However, a myriad of drugs and chemicals affects CNS with severe resultant effects on the brainstem.

Methods: In view of this, a number of literature were assessed for information on the most sensitive part of brain, drugs and chemicals that act on the brainstem and clinical benefit and risk assessment of such drugs and chemicals.

Results: Findings have shown that brainstem regulates heartbeat, respiration and because it connects the brain and spinal cord, all the drugs that act on the spinal cord may overall affect the systems controlled by the spinal cord and brain. The message is sent and received by temporal lobe, occipital lobe, frontal lobe, parietal lobe and cerebellum.

Conclusion: Hence, the chemical functional groups of the brainstem and drugs acting on brainstem are complementary, and may produce either stimulation or depression of CNS.

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脑干作用药物的化学及作用。

背景:脑是最敏感的器官，而脑干是中枢神经系统(CNS)最重要的部分。它连接着大脑和脊髓。然而，大量的药物和化学物质会影响中枢神经系统，对脑干产生严重的影响。方法:针对脑干最敏感部位、作用于脑干的药物和化学物质以及此类药物和化学物质的临床获益和风险评估，对多篇文献进行评估。结果:研究结果表明，脑干调节心跳、呼吸，因为它连接大脑和脊髓，所有作用于脊髓的药物都可能总体上影响由脊髓和大脑控制的系统。信息通过颞叶、枕叶、额叶、顶叶和小脑发送和接收。结论:脑干化学官能团与作用于脑干的药物是互补的，可能对中枢神经系统产生刺激或抑制作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Central nervous system agents in medicinal chemistry Psychology-Neuropsychology and Physiological Psychology

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.