Hormones and their Structural and Functional Effects on the Brain: How Can We Change our Practice Moving Forward?

4区医学 Q2 Medicine Pediatric endocrinology reviews : PER Pub Date : 2019-06-01 DOI:10.17458/per.vol16.2019.chm.hormonestructuraleffects

Bonnie McCann-Crosby, Laurel Hyle, David Mann, Sheila Gunn, Katherine Flynn, Jennifer Bercaw-Pratt, Oluyemisi Adeyemi, Jennifer Dietrich, Duong Tu, Paul F Austin, V Reid Sutton, Marni Axelrad, Lefkothea Karaviti

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Abstract

Is hormone treatment an invasive procedure? In this paper, we discuss aspects related to the choice of treating disorders of sex development (DSD) using hormones. Specifically, we focus on some of the challenging issues related to this treatment and the need to establish a standard of care for the use of hormone therapy in this patient population. The objectives of this paper are to: 1) Enhance understanding of the uncertainties in the decision-making process regarding hormonal interventions to treat patients with DSD. 2) Recognize that the effects of hormonal interventions might require a consent process similar to that applied for surgical procedures. 3) Emphasize the need to establish treatment algorithms that could form the basis of a standard of care for this patient population.

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激素及其对大脑的结构和功能影响:我们如何改变我们的实践?

激素治疗是一种侵入性手术吗?在本文中，我们讨论了有关选择使用激素治疗性发育障碍(DSD)的方面。具体来说，我们关注的是与这种治疗相关的一些具有挑战性的问题，以及在这种患者群体中建立激素治疗的护理标准的必要性。本文的目的是:1)提高对激素干预治疗DSD患者决策过程中的不确定性的认识。2)认识到激素干预的影响可能需要一个类似于外科手术的同意程序。3)强调建立治疗算法的必要性，这些算法可以形成针对这一患者群体的护理标准的基础。

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Pediatric endocrinology reviews : PER Medicine-Endocrinology, Diabetes and Metabolism

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期刊介绍： PEDIATRIC ENDOCRINOLOGY REVIEWS (PER) publishes scholarly review articles in all areas of clinical and experimental Endocrinology, Diabetes, Nutrition and Metabolism. PER is intended for practicing pediatricians, pediatric endocrinologists, pediatric diabetologists, pediatric gastroenterologists, neonatologists, pediatric gynecologists, nutritionists, sport physicians and pediatricians-in-training. PER will also publish topics on specific subjects or as proceedings of scientific meetings in the above fields of interest. All articles, whether invited or direct contributions, are peer-reviewed. PER publishes correspondence, book reviews, a meeting calendar and meeting reports.

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