HPV genoprevalence and HPV knowledge in young women in Mongolia, five years following a pilot 4vHPV vaccination campaign

Tsetsegsaikhan Batmunkh , Claire von Mollendorf , Khosbayar Tulgaa , Unursaikhan Surenjav , Marguerite T. Dalmau , Narantuya Namjil , Battsetseg Tsedevdamba , Sambuu Tsegmed , Jalserd Enkhmaa , Suzanne M. Garland , Kim Mulholland
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引用次数: 8

Abstract

Background

In a 2012 pilot, 9111 Mongolian girls aged 11–17 years received three doses of the quadrivalent (4vHPV) vaccine, Gardasil®. This is the first study to measure early vaccine effectiveness and assess knowledge and attitudes of young women in Mongolia in relation to the human papillomavirus (HPV), the vaccine and cervical cancer.

Methods

A cohort of women vaccinated in 2012 (n = 726) and an unvaccinated cohort (n = 790) provided self-administered vaginal swabs for detection of high-risk HPV genotypes 16, 18/45, 31, 33, 35, 39, 51, 52, 56, 58, 59, 66, 68 five years following vaccination. Participant knowledge and attitudes were assessed through a questionnaire.

Results

A total of 1882 questionnaires and 1516 self-administered vaginal swabs were analyzed. The prevalence of any HRHPV was 39.5% among both cohorts. The prevalence of vaccine-targeted HPV types was significantly lower in the vaccinated cohort than unvaccinated: 4.8% and 17.2% respectively. The 4vHPV was shown to be protective against HRHPV 16, 18/45 with 75% vaccine effectiveness. Participant knowledge was low.

Conclusions

This study demonstrates that the 4vHPV is associated with reduced vaccine-targeted HPV detection rates in young Mongolian women. The questionnaire results highlight a need for awareness-raising initiatives in Mongolia on HPV, the vaccine and cervical cancer.

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蒙古青年妇女的HPV基因患病率和HPV知识,在开展4vHPV疫苗接种试点运动5年后
在2012年的一项试点中,9111名11-17岁的蒙古女孩接受了三剂四价(4vHPV)疫苗Gardasil®。这是第一项衡量早期疫苗有效性并评估蒙古年轻妇女对人乳头瘤病毒(HPV)、疫苗和宫颈癌的知识和态度的研究。方法一组2012年接种疫苗的妇女(n = 726)和一组未接种疫苗的妇女(n = 790)在接种疫苗5年后自行阴道拭子检测高危HPV基因型16、18/45、31、33、35、39、51、52、56、58、59、66、68。通过问卷评估参与者的知识和态度。结果共收集问卷1882份,自行阴道拭子1516份。两组人群中HRHPV的患病率均为39.5%。在接种疫苗的人群中,疫苗靶向型HPV的患病率明显低于未接种疫苗的人群:分别为4.8%和17.2%。4vHPV被证明对HRHPV 16,18 /45具有保护作用,疫苗有效性为75%。参与者的知识水平较低。结论本研究表明,4vHPV与蒙古年轻女性疫苗靶向HPV检出率降低有关。问卷调查结果突出表明,蒙古需要在人乳头瘤病毒、疫苗和子宫颈癌方面开展提高认识行动。
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期刊介绍: The official Journal of the International Papillomavirus Society Papillomavirus Research (PVR), the Journal of HPV and other Small DNA Tumor Viruses publishes innovative papers related to all aspects of papillomaviruses and other small DNA tumor viruses. The official journal of the International Papillomavirus Society, PVR is an open access publication that aims to bring together virologists, immunologists, epidemiologists and clinicians working in the booming field of HPV and animal papillomaviruses, polyomaviruses and other small DNA tumor viruses and their associated diseases, in order to foster and facilitate interdisciplinary communication. The journal welcomes original research articles, reviews, short communications, opinion articles and regional update reports on papillomaviruses and other tumor viruses in the following sections: a. Biology of papillomaviruses and related viruses from life cycle to cancer b. Epidemiology etiology and natural history studies c. Natural and induced immunity including vaccine research d. Intervention studies and strategies including i. Clinical studies and trials ii. HPV treatments iii. HPV vaccination programs iv. Diagnostics and screening e. Infection and disease prevention, modeling studies f. Guidelines and public health recommendations g. HPV Studies in special populations Regional and local studies on these viruses.
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