Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil.

IF 2.3 Q4 CELL & TISSUE ENGINEERING Current Stem Cell Reports Pub Date : 2018-06-01 Epub Date: 2018-04-30 DOI:10.1007/s40778-018-0127-7

Xinxin Huang, Thao Trinh, Arafat Aljoufi, Hal E Broxmeyer

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引用次数: 48

Abstract

Purpose of review: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell systems. Stem cells for different lineages/tissues reside in distinct niches, and are exposed to diverse oxygen concentrations. Recent studies have revealed the importance of the hypoxia signaling pathway for stem cell functions.

Recent findings: Hypoxia and HIFs contribute to maintenance of embryonic stem cells, generation of induced pluripotent stem cells, functionality of hematopoietic stem cells, and survival of leukemia stem cells. Harvest and collection of mouse bone marrow and human cord blood cells in ambient air results in fewer hematopoietic stem cells recovered due to the phenomenon of Extra PHysiologic Oxygen Shock/Stress (EPHOSS).

Summary: Oxygen is an important factor in the stem cell microenvironment. Hypoxia signaling and HIFs play important roles in modeling cellular metabolism in both stem cells and niches to regulate stem cell biology, and represent an additional dimension that allows stem cells to maintain an undifferentiated status and multilineage differentiation potential.

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干细胞调控中的缺氧信号通路:好与坏。

综述目的:本文综述了缺氧和缺氧诱导因子(hif)在干细胞生物学调控中的作用，特别关注了几种干细胞系统的维持、分化和应激反应。不同谱系/组织的干细胞存在于不同的生态位中，并暴露于不同的氧浓度。最近的研究揭示了缺氧信号通路对干细胞功能的重要性。最近的研究发现:缺氧和hfs有助于胚胎干细胞的维持、诱导多能干细胞的产生、造血干细胞的功能和白血病干细胞的存活。在环境空气中采集小鼠骨髓和人脐带血细胞，由于额外生理性氧休克/应激(EPHOSS)现象，恢复的造血干细胞较少。摘要:氧是干细胞微环境中的一个重要因素。缺氧信号和hif在干细胞和小生境的细胞代谢建模中发挥重要作用，以调节干细胞生物学，并代表了允许干细胞保持未分化状态和多谱系分化潜力的额外维度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Stem Cell Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of stem cell research, therapy, ethics, commercialization, and policy. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.