Urinary CXCL9 and CXCL10 Levels and Acute Renal Graft Rejection.

IF 0.3 Q4 TRANSPLANTATION International Journal of Organ Transplantation Medicine Pub Date : 2019-01-01 Epub Date: 2019-05-01
H S Ciftci, T Tefik, M K Savran, E Demir, Y Caliskan, Y D Ogret, T Oktar, O Sanlı, T Kocak, Y Ozluk, F S Oguz, I Kilicaslan, F Aydın, A Turkmen, I Nane
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引用次数: 0

Abstract

Background: Monitoring of chemokines, CXCL9 and CXCL10, in serum may present a non-invasive detection method for rejection.

Objective: To investigate the relationship between urinary levels of CXCL9 and CXCL10 and graft function following renal transplantation.

Methods: 75 living-related donor renal transplant recipients were studied. Urinary levels of chemokines were collected pre-operatively, on post-operative 1st day, 7th day, 1st month, 3rd month, and at the time of rejection. Chemokines levels were assayed using and enzyme-linked immunosorbent assay.

Results: Clinical variables were monitored. 10 (15%) patients had biopsy-proven rejection during the follow-up period. The urinary CXCL9 level in those with rejection was significantly higher than that in those with non-rejection group at the 1st day (p<0.001), 7th day (p<0.001), and at the time of rejection (p=0.002). The urinary CXCL10 level was also significantly higher in those with rejection compared with non-rejection group at 1st day (p<0.001), 7th day (p<0.001), and at the time of rejection (p=0.001). Serum creatinine level was strongly correlated with the urinary CXCL9 and CXCL10 levels at the time of rejection (r=0.615, p=0.002; and r=0.519, p=0.022, respectively). Among those with T cell-mediated rejections the mean urinary CXCL10 level increased to as high as 258.12 ng/mL.

Conclusion: Urinary CXCL9 and CXCL10 levels might have a predictive value for T cell-mediated rejection in early post-transplantation period. Measurement of urinary CXCL9 and CXCL10 levels could provide an additional tool for the diagnosis of rejection.

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尿CXCL9和CXCL10水平与急性肾移植排斥反应。
背景:监测血清中的趋化因子CXCL9和CXCL10可能是一种无创检测排斥反应的方法。目的:探讨肾移植术后尿CXCL9、CXCL10水平与移植物功能的关系。方法:对75例活体肾移植受者进行研究。收集术前、术后第1天、第7天、第1个月、第3个月和排斥反应时尿液趋化因子水平。采用酶联免疫吸附法检测趋化因子水平。结果:监测临床变量。10例(15%)患者在随访期间活检证实有排斥反应。排异反应组尿液CXCL9水平在移植后第1天(p天)(p天)(p天)显著高于非排异反应组(p天)。结论:尿CXCL9和CXCL10水平可能对移植后早期T细胞介导的排异反应具有预测价值。尿液中CXCL9和CXCL10水平的测定可以为排异反应的诊断提供额外的工具。
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来源期刊
CiteScore
1.60
自引率
0.00%
发文量
0
审稿时长
12 weeks
期刊介绍: The International Journal of Organ Transplantation Medicine (IJOTM) is a quarterly peer-reviewed English-language journal that publishes high-quality basic sciences and clinical research on transplantation. The scope of the journal includes organ and tissue donation, procurement and preservation; surgical techniques, innovations, and novelties in all aspects of transplantation; genomics and immunobiology; immunosuppressive drugs and pharmacology relevant to transplantation; graft survival and prevention of graft dysfunction and failure; clinical trials and population analyses in the field of transplantation; transplant complications; cell and tissue transplantation; infection; post-transplant malignancies; sociological and ethical issues and xenotransplantation.
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