Rectal gastrointestinal stromal tumour: What do we know in 2017? A systematic review protocol

Surennaidoo Naiken , Ailsa Craig , Noémie Guedj , Nelson Peixoto , Guillaume Zufferey
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引用次数: 1

Abstract

Introduction

Gastrointestinal stromal tumour is a pathology that originates from the interstitial cells of Cajal and differentiates from other mesenchymal neoplasm by expression of CD117 oncogene on Immunohistochemistry test. Colon and Rectal GISTs constitutes of approximately 5% of all gastrointestinal GISTs. The past decade has witnessed a dramatic change in the treatment of rectal cancer. Preoperative, perioperative and postoperative, management has changed thanks to new chemotherapy regimens and emergence of novel surgical techniques. Our aim is to investigate if same change can be implemented for rectal GISTs management.

Methods and analysis

This protocol is compliant with the Preferred Reporting Items for Systematic Review and Meta-Analysis protocols (PRISMA-P) guidelines. Exclusion and inclusion criteria are outlined within this protocol. Points of interest and objectives are described within this protocol. The search strategy, aims to identify all articles on “Rectal GISTs”.

Discussion

The choice of resection type surgery depends upon the location and size of rectal GIST. Neoadjuvant Imatinib therapy yields tumour shrinkage in at least 50% and is associated with a prolonged disease-free survival for intermediate and high-risk patients. This review will also allow a summary clinicopathological features and prognostic factors of rectal GISTs.

Ethics and dissemination

The Centre for Reviews and Dissemination, University of York acknowledged that this systematic review is within the register scope. This review will be published in a peer-reviewed journal and will be presented at various national and international conferences.

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直肠胃肠道间质瘤:2017年我们知道些什么?系统评价方案
星形肠间质瘤是一种起源于Cajal间质细胞的病理,通过免疫组化检测CD117癌基因的表达与其他间质肿瘤区分开来。结肠和直肠胃肠道间质瘤约占胃肠道间质瘤的5%。在过去的十年里,直肠癌的治疗发生了巨大的变化。由于新的化疗方案和新手术技术的出现,术前、围手术期和术后的治疗已经发生了变化。我们的目的是研究同样的改变是否可以用于直肠胃肠道间质瘤的治疗。方法和分析本方案符合系统评价和荟萃分析方案的首选报告项目(PRISMA-P)指南。排除和纳入标准在本方案中列出。本协议中描述了兴趣点和目标。搜索策略,旨在识别所有关于“直肠gist”的文章。讨论切除手术的选择取决于直肠间质瘤的位置和大小。新辅助伊马替尼治疗可使肿瘤缩小至少50%,并可延长中高危患者的无病生存期。本综述还将总结直肠胃肠道间质瘤的临床病理特征和预后因素。伦理与传播约克大学评论与传播中心承认,该系统评论属于注册范围。这篇综述将发表在同行评议的期刊上,并将在各种国内和国际会议上发表。
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期刊介绍: IJS Protocols is the first peer-reviewed, international, open access journal seeking to publish research protocols across across the full breadth of the surgical field. We are aim to provide rapid submission to decision times whilst maintaining a high quality peer-review process.
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