Essential Ingredients and Innovations in the Design and Analysis of Group-Randomized Trials.

IF 21.4 1区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Annual Review of Public Health Pub Date : 2020-04-02 Epub Date: 2019-12-23 DOI:10.1146/annurev-publhealth-040119-094027

David M Murray, Monica Taljaard, Elizabeth L Turner, Stephanie M George

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引用次数: 25

Abstract

This article reviews the essential ingredients and innovations in the design and analysis of group-randomized trials. The methods literature for these trials has grown steadily since they were introduced to the biomedical research community in the late 1970s, and we summarize those developments. We review, in addition to the group-randomized trial, methods for two closely related designs, the individually randomized group treatment trial and the stepped-wedge group-randomized trial. After describing the essential ingredients for these designs, we review the most important developments in the evolution of their methods using a new bibliometric tool developed at the National Institutes of Health. We then discuss the questions to be considered when selecting from among these designs or selecting the traditional randomized controlled trial. We close with a review of current methods for the analysis of data from these designs, a case study to illustrate each design, and a brief summary.

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组随机试验设计和分析的基本成分和创新。

本文综述了组随机试验设计和分析的基本要素和创新之处。自20世纪70年代末引入生物医学研究界以来，这些试验的方法文献稳步增长，我们总结了这些发展。除了组随机试验外，我们还回顾了两个密切相关的设计方法，即单独随机组治疗试验和阶梯楔形组随机试验。在描述了这些设计的基本成分之后，我们使用美国国立卫生研究院开发的一种新的文献计量工具，回顾了这些设计方法演变过程中最重要的进展。然后讨论从这些设计中选择或选择传统的随机对照试验时需要考虑的问题。最后，我们回顾了这些设计的数据分析的当前方法，一个案例研究来说明每个设计，并简要总结。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual Review of Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

26.60

自引率

1.40%

发文量

审稿时长

>12 weeks

期刊介绍： The Annual Review of Public Health has been a trusted publication in the field since its inception in 1980. It provides comprehensive coverage of important advancements in various areas of public health, such as epidemiology, biostatistics, environmental health, occupational health, social environment and behavior, health services, as well as public health practice and policy. In an effort to make the valuable research and information more accessible, the current volume has undergone a transformation. Previously, access to the articles was restricted, but now they are available to everyone through the Annual Reviews' Subscribe to Open program. This open access approach ensures that the knowledge and insights shared in these articles can reach a wider audience. Additionally, all the published articles are licensed under a CC BY license, allowing users to freely use, distribute, and build upon the content, while giving appropriate credit to the original authors.

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