Structure and Mechanism of P-Type ATPase Ion Pumps.

IF 12.1 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Annual review of biochemistry Pub Date : 2020-06-20 Epub Date: 2020-12-24 DOI:10.1146/annurev-biochem-010611-112801
Mateusz Dyla, Magnus Kjærgaard, Hanne Poulsen, Poul Nissen
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引用次数: 83

Abstract

P-type ATPases are found in all kingdoms of life and constitute a wide range of cation transporters, primarily for H+, Na+, K+, Ca2+, and transition metal ions such as Cu(I), Zn(II), and Cd(II). They have been studied through a wide range of techniques, and research has gained very significant insight on their transport mechanism and regulation. Here, we review the structure, function, and dynamics of P2-ATPases including Ca2+-ATPases and Na,K-ATPase. We highlight mechanisms of functional transitions that are associated with ion exchange on either side of the membrane and how the functional cycle is regulated by interaction partners, autoregulatory domains, and off-cycle states. Finally, we discuss future perspectives based on emerging techniques and insights.

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p型atp酶离子泵的结构与机理。
p型atp酶存在于所有生命王国中,构成了广泛的阳离子转运体,主要用于H+, Na+, K+, Ca2+和过渡金属离子,如Cu(I), Zn(II)和Cd(II)。人们通过广泛的技术对它们进行了研究,并对它们的转运机制和调控获得了非常重要的见解。本文综述了Ca2+- atp酶和Na, k - atp酶等p2 - atp酶的结构、功能和动力学。我们强调了与膜两侧离子交换相关的功能转变机制,以及功能周期如何受到相互作用伙伴、自调节域和非循环状态的调节。最后,我们讨论了基于新兴技术和见解的未来前景。
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来源期刊
Annual review of biochemistry
Annual review of biochemistry 生物-生化与分子生物学
CiteScore
33.90
自引率
0.00%
发文量
31
期刊介绍: The Annual Review of Biochemistry, in publication since 1932, sets the standard for review articles in biological chemistry and molecular biology. Since its inception, these volumes have served as an indispensable resource for both the practicing biochemist and students of biochemistry.
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