Math, science, history, unraveling the mystery—That all started with de novo!

Q4 Biochemistry, Genetics and Molecular Biology EuPA Open Proteomics Pub Date : 2019-03-01 DOI:10.1016/j.euprot.2019.07.011
Ekaterina Ilgisonis, Olga Kiseleva, Ksenia Kuznetsova Dr.
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Abstract

This work on solving the mystery of words encoded by amino acids in peptides was derived by the YPIC-EuPA Challenge. We received a dry synthetic peptide sample and performed a mass spectrometric analysis followed by de novo peptide sequencing. As a result, a part of “Rays of positive electricity and their application to chemical analyses” by J.J.Tomson was found to be encoded in the peptides of the sample. The words were first revealed from the peptides, that matched by Google search to find the answer. After that, the answer was validated using a standard proteomic search against a database constructed from the quotation found.

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数学、科学、历史、揭开神秘——这一切都是从从头开始的!
这项关于解决肽中氨基酸编码的单词之谜的工作是由YPIC-EuPA挑战衍生的。我们收到了一个干燥的合成肽样品,并进行了质谱分析,随后进行了从头开始的肽测序。结果,J.J.Tomson的“正电射线及其在化学分析中的应用”的一部分被发现编码在样品的肽中。这些词首先从肽中显示出来,然后通过谷歌搜索找到答案。之后,使用标准的蛋白质组学搜索对从所找到的引文构建的数据库进行验证。
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来源期刊
EuPA Open Proteomics
EuPA Open Proteomics Biochemistry, Genetics and Molecular Biology-Biochemistry
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审稿时长
103 days
期刊最新文献
Proceedings of the EuBIC-MS 2020 Developers’ Meeting Editorial: The next generation in (EuPA Open) Proteomics Aims & scope Proceedings of the EuBIC Winter School 2019 Introducing the YPIC challenge
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