Megha Nataraj, Arun G Maiya, Gagana Karkada, Manjunatha Hande, Gabriel S Rodrigues, Rajgopal Shenoy, Shiva S Prasad
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引用次数: 19
Abstract
Background: Individuals with diabetes may develop diabetic foot ulcers due to diabetic peripheral neuropathy. Multiple factors influence the ulcer healing process; oxygen helps in facilitating the different stages of wound healing.
Objective: The objective of this systematic review was to analyze the different levels of evidence available in the application of topical oxygen therapy, warm oxygen therapy, or other modes of topical oxygen delivery in the healing dynamics of diabetic foot ulcers.
Methods: Databases searched included Pubmed/Medline, Science Direct, Web of Science, Scopus, Cochrane, and CINAHL. The eligibility criteria of studies included participants ≥18 years with chronic non-healing diabetic foot ulcer (duration ≥3 months) receiving warm oxygen or topical oxygen therapy (TOT), and other modes of topical oxygen administration, which were compared with standard care group. Randomized and non-randomized studies were included. The primary outcome measure assessed was the rate of wound healing or wound closure.
Results: The review included 5 studies which used different modes of topical oxygen administration. The healing trajectory of the wounds was completely achieved in low-grade ulcers (grade 1), whereas all high-grade ulcers (grades 2, 3, and above) showed either 100% or 50% healing with a reduction in ulcer size and ulcer tissue depth.
Conclusion: Topical oxygen therapy facilitates wound healing dynamics among individuals with chronic diabetic foot ulcers.
背景:糖尿病患者可能因糖尿病周围神经病变而发展为糖尿病足溃疡。多种因素影响溃疡愈合过程;氧气有助于促进伤口愈合的不同阶段。目的:本系统综述的目的是分析不同水平的可用证据的应用表面氧治疗，热氧治疗，或其他模式的表面氧输送在糖尿病足溃疡的愈合动力学。方法:检索Pubmed/Medline、Science Direct、Web of Science、Scopus、Cochrane、CINAHL等数据库。研究的入选标准包括年龄≥18岁的慢性未愈合糖尿病足溃疡患者(病程≥3个月)，接受温氧或局部氧治疗(TOT)及其他方式的局部氧给药，并与标准护理组进行比较。包括随机和非随机研究。评估的主要结局指标是伤口愈合或愈合的速度。结果:本综述纳入5项采用不同给氧方式的研究。低级别溃疡(1级)的伤口愈合轨迹完全实现，而所有高级别溃疡(2级、3级及以上)显示100%或50%愈合，溃疡大小和溃疡组织深度减少。结论:局部氧疗促进了慢性糖尿病足溃疡患者的伤口愈合动态。
期刊介绍：
The Review of Diabetic Studies (RDS) is the society"s peer-reviewed journal published quarterly. The purpose of The RDS is to support and encourage research in biomedical diabetes-related science including areas such as endocrinology, immunology, epidemiology, genetics, cell-based research, developmental research, bioengineering and disease management.
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