Does Pseudomonas aeruginosa Colonization Affect Exercise Capacity in CF?

IF 2 Q3 RESPIRATORY SYSTEM Pulmonary Medicine Pub Date : 2019-12-09 eCollection Date: 2019-01-01 DOI:10.1155/2019/3786245

Asterios Kampouras, Elpis Hatziagorou, Vasiliki Avramidou, Vasiliki Georgopoulou, Fotios Kirvassilis, John Tsanakas

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引用次数: 3

Abstract

Introduction: Cardio-Pulmonary Exercise Testing (CPET) has been recognized as a valuable method in assessing disease burden and exercise capacity among CF patients.

Aim: To evaluate whether Pseudomonas aeruginosa colonization status affects Exercise Capacity, LCI and High-Resolution Computed Tomography (HRCT) indices among patients with CF; to check if Pseudomonas colonization can predict exercise intolerance.

Subjects: Seventy-eight (78) children and adults with CF (31 males) mean (range) age 17.08 (6.75; 24.25) performed spirometry, Multiple Breath Washout (MBW) and CPET along with HRCT on the same day during their admission or follow up visit.

Results: 78 CF patients (mean FEV1: 83.3% mean LCI: 10.9 and mean VO₂ peak: 79.1%) were evaluated: 33 were chronically colonized with Pseudomonas aeruginosa, 24 were intermittently colonized whereas 21 were Pseudomonas free. Statistically significant differences were observed among the three groups in: peak oxygen uptake % predicted (VO₂ peak% (p < 0.001), LCI (p < 0.001), as well as FEV1% (p < 0.001) and FVC% (p < 0.001). Pseudomonas colonization could predict VO₂ peak% (p < 0.001, r ²: -0.395).

Conclusion: Exercise capacity as reflected by peak oxygen uptake is reduced in Pseudomonas colonized patients and reflects lung structural damages as shown on HRCT. Pseudomonas colonization could predict exercise limitation among CF patients.

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铜绿假单胞菌的定植是否影响CF患者的运动能力?

心肺运动试验(CPET)已被认为是评估CF患者疾病负担和运动能力的一种有价值的方法。目的:探讨铜绿假单胞菌定殖状态对CF患者运动能力、LCI和HRCT指标的影响;检查假单胞菌的定植是否可以预测运动不耐受。受试者:78(78)名CF儿童和成人(31名男性)，平均(范围)年龄17.08 (6.75;24.25)在入院或随访的同一天进行肺活量测定、多次呼吸冲洗(MBW)和CPET以及HRCT。结果:78例CF患者(平均FEV1: 83.3%，平均LCI: 10.9，平均VO2峰值:79.1%):慢性定植铜绿假单胞菌33例，间歇定植24例，无假单胞菌21例。三组患者预测峰值摄氧量% (VO2峰值%)(p < 0.001)、LCI (p < 0.001)、FEV1% (p < 0.001)、FVC% (p < 0.001)差异均有统计学意义。假单胞菌定殖可以预测VO2峰值% (p < 0.001, r 2: -0.395)。结论:HRCT显示假单胞菌定殖患者通过峰值摄氧量反映的运动能力降低，反映了肺结构损伤。假单胞菌定植可预测CF患者的运动限制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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