A Link Between Brain Insulin Resistance and Cognitive Dysfunctions: Targeting Ca2+/cAMP Signalling.

Q3 Psychology Central nervous system agents in medicinal chemistry Pub Date : 2020-01-01 DOI:10.2174/1871524920666200129121232

Leandro B Bergantin

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引用次数: 5

Abstract

Background: A correlation between cognitive dysfunctions and brain insulin resistance has been established by several clinical and experimental studies. Consistent data support that people diagnosed with brain insulin resistance, resulted from diabetes, have shown an increased risk of presenting cognitive dysfunctions, clinical signs of dementia and depression, then speculating a role of dysregulations related to insulin signalling in these diseases. Furthermore, it is currently discussed that Ca2+ signalling, and its dysregulations, may be a factor which could correlate with brain insulin resistance and cognitive dysfunctions.

Objective: Following this, revealing this interplay between these diseases may provide novel insights into the pathogenesis of such diseases.

Methods: Publications covering topics such as Ca2+ signalling, diabetes, depression and dementia (alone or combined) were collected by searching PubMed and EMBASE.

Results: The controlling of both neurotransmitters/hormones release and neuronal death could be achieved through modulating Ca2+ and cAMP signalling pathways (Ca2+/cAMP signalling).

Conclusion: Taking into account our previous reports on Ca2+/cAMP signalling, and considering a limited discussion in the literature on the role of Ca2+/cAMP signalling in the link between cognitive dysfunctions and brain insulin resistance, this article has comprehensively discussed the role of these signalling pathways in this link (between cognitive dysfunctions and brain insulin resistance).

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脑胰岛素抵抗和认知功能障碍之间的联系:针对Ca2+/cAMP信号传导。

背景:认知功能障碍与脑胰岛素抵抗之间的相关性已被一些临床和实验研究所证实。一致的数据支持，被诊断为由糖尿病引起的脑胰岛素抵抗的人，表现出认知功能障碍、痴呆和抑郁临床症状的风险增加，然后推测与胰岛素信号失调有关的作用在这些疾病中。此外，目前正在讨论Ca2+信号及其失调可能是与脑胰岛素抵抗和认知功能障碍相关的一个因素。目的:在此基础上，揭示这些疾病之间的相互作用可能为这些疾病的发病机制提供新的见解。方法:通过检索PubMed和EMBASE收集涵盖Ca2+信号、糖尿病、抑郁症和痴呆(单独或联合)等主题的出版物。结果:神经递质/激素释放和神经元死亡均可通过调节Ca2+和cAMP信号通路(Ca2+/cAMP signaling)来实现。结论:考虑到我们之前关于Ca2+/cAMP信号传导的报道，并考虑到文献中关于Ca2+/cAMP信号传导在认知功能障碍和脑胰岛素抵抗之间联系中的作用的有限讨论，本文全面讨论了这些信号通路在这一联系中的作用(认知功能障碍和脑胰岛素抵抗之间)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Central nervous system agents in medicinal chemistry Psychology-Neuropsychology and Physiological Psychology

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.