Fine intercellular connections in development: TNTs, cytonemes, or intercellular bridges?

IF 4.1 Q2 CELL BIOLOGY Cell Stress Pub Date : 2020-01-07 DOI:10.15698/cst2020.02.212
Olga Korenkova, Anna Pepe, Chiara Zurzolo
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引用次数: 50

Abstract

Intercellular communication is a fundamental property of multicellular organisms, necessary for their adequate responses to changing environment. Tunneling nanotubes (TNTs) represent a novel means of intercellular communication being a long cell-to-cell conduit. TNTs are actively formed under a broad range of stresses and are also proposed to exist under physiological conditions. Development is a physiological condition of particular interest, as it requires fine coordination. Here we discuss whether protrusions shown to exist during embryonic development of different species could be TNTs or if they represent other types of cell structure, like cytonemes or intercellular bridges, that are suggested to play an important role in development.

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发育中的精细细胞间连接:tnt,细胞素,还是细胞间桥?
细胞间通讯是多细胞生物的基本特性,是它们对环境变化作出充分反应的必要条件。隧道纳米管(TNTs)是一种新的细胞间通信方式,是一种细胞间的长通道。tnt是在广泛的应激条件下积极形成的,也被认为存在于生理条件下。发育是一种特别有趣的生理状况,因为它需要精细的协调。在这里,我们讨论了在不同物种的胚胎发育过程中显示存在的突起是否可能是tnt,或者它们是否代表了其他类型的细胞结构,如细胞素或细胞间桥,这些结构被认为在发育中起重要作用。
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来源期刊
Cell Stress
Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)
CiteScore
13.50
自引率
0.00%
发文量
21
审稿时长
15 weeks
期刊介绍: Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.
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