Precision Medicine in Non-Communicable Diseases.

Q2 Biochemistry, Genetics and Molecular Biology High-Throughput Pub Date : 2020-02-07 DOI:10.3390/ht9010003

Giuseppe Novelli, Michela Biancolella, Andrea Latini, Aldo Spallone, Paola Borgiani, Marisa Papaluca

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引用次数: 13

Abstract

The increase in life expectancy during the 20th century ranks as one of society's greatest achievements, with massive growth in the numbers and proportion of the elderly, virtually occurring in every country of the world. The burden of chronic diseases is one of the main consequences of this phenomenon, severely hampering the quality of life of elderly people and challenging the efficiency and sustainability of healthcare systems. Non-communicable diseases (NCDs) are considered a global emergency responsible for over 70% of deaths worldwide. NCDs are also the basis for complex and multifactorial diseases such as hypertension, diabetes, and obesity. The epidemics of NCDs are a consequence of a complex interaction between health, economic growth, and development. This interaction includes the individual genome, the microbiome, the metabolome, the immune status, and environmental factors such as nutritional and chemical exposure. To counteract NCDs, it is therefore essential to develop an innovative, personalized, preventative, early care model through the integration of different molecular profiles of individuals to identify both the critical biomarkers of NCD susceptibility and to discover novel therapeutic targets.

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非传染性疾病的精准医疗。

20世纪预期寿命的增加是社会最伟大的成就之一，老年人的数量和比例大幅增长，几乎发生在世界上每个国家。慢性病负担是这一现象的主要后果之一，严重影响老年人的生活质量，并对卫生保健系统的效率和可持续性提出挑战。非传染性疾病(NCDs)被认为是造成全球70%以上死亡的全球性紧急情况。非传染性疾病也是高血压、糖尿病和肥胖等复杂和多因素疾病的基础。非传染性疾病的流行是卫生、经济增长和发展之间复杂相互作用的结果。这种相互作用包括个体基因组、微生物组、代谢组、免疫状态和环境因素，如营养和化学暴露。因此，为了对抗非传染性疾病，必须通过整合个体的不同分子谱，开发一种创新的、个性化的、预防性的早期护理模式，以确定非传染性疾病易感性的关键生物标志物，并发现新的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

High-Throughput Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

9 weeks

期刊介绍： High-Throughput (formerly Microarrays, ISSN 2076-3905) is a multidisciplinary peer-reviewed scientific journal that provides an advanced forum for the publication of studies reporting high-dimensional approaches and developments in Life Sciences, Chemistry and related fields. Our aim is to encourage scientists to publish their experimental and theoretical results based on high-throughput techniques as well as computational and statistical tools for data analysis and interpretation. The full experimental or methodological details must be provided so that the results can be reproduced. There is no restriction on the length of the papers. High-Throughput invites submissions covering several topics, including, but not limited to: -Microarrays -DNA Sequencing -RNA Sequencing -Protein Identification and Quantification -Cell-based Approaches -Omics Technologies -Imaging -Bioinformatics -Computational Biology/Chemistry -Statistics -Integrative Omics -Drug Discovery and Development -Microfluidics -Lab-on-a-chip -Data Mining -Databases -Multiplex Assays