{"title":"Uterus transplantation: transition from experimental to clinical procedure.","authors":"Mats Brännström","doi":"10.23736/S0026-4784.19.04482-4","DOIUrl":null,"url":null,"abstract":"<p><p>Uterus transplantation is a novel treatment to treat uterine factor infertility. This type of infertility is due to absence of an anatomical or functional uterus. This review covers important research findings in the field, and this research formed the base for introduction of uterus transplantation as an experimental clinical procedure. The basic animal-research investigated central facets such as surgery, immunosuppression, ischemia-reperfusion injury, rejection, and fertility. The first clinical uterus transplantation trial was started in 2013 and this was a live donor trial. The first live birth was reported in 2014 and this has been followed by a number of births from the initial trial in Sweden and in several other parts of the world. The uterus transplantations procedures and the live births that have been scientifically reported will be discussed in this review. Lastly, some aspects for an efficient transition from an experimental phase into a clinical phase of uterus transplantation will be discussed.</p>","PeriodicalId":18745,"journal":{"name":"Minerva ginecologica","volume":"71 6","pages":"460-466"},"PeriodicalIF":1.0000,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Minerva ginecologica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23736/S0026-4784.19.04482-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 4
Abstract
Uterus transplantation is a novel treatment to treat uterine factor infertility. This type of infertility is due to absence of an anatomical or functional uterus. This review covers important research findings in the field, and this research formed the base for introduction of uterus transplantation as an experimental clinical procedure. The basic animal-research investigated central facets such as surgery, immunosuppression, ischemia-reperfusion injury, rejection, and fertility. The first clinical uterus transplantation trial was started in 2013 and this was a live donor trial. The first live birth was reported in 2014 and this has been followed by a number of births from the initial trial in Sweden and in several other parts of the world. The uterus transplantations procedures and the live births that have been scientifically reported will be discussed in this review. Lastly, some aspects for an efficient transition from an experimental phase into a clinical phase of uterus transplantation will be discussed.
期刊介绍：
The journal Minerva Ginecologica publishes scientific papers on obstetrics and gynecology. Manuscripts may be submitted in the form of editorials, original articles, review articles, case reports, therapeutical notes, special articles and letters to the Editor. Manuscripts are expected to comply with the instructions to authors which conform to the Uniform Requirements for Manuscripts Submitted to Biomedical Editors by the International Committee of Medical Journal Editors (www.icmje.org). Articles not conforming to international standards will not be considered for acceptance.
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