Mitochondrial Proteases: Multifaceted Regulators of Mitochondrial Plasticity.

IF 12.1 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Annual review of biochemistry Pub Date : 2020-06-20 Epub Date: 2020-02-19 DOI:10.1146/annurev-biochem-062917-012739
Soni Deshwal, Kai Uwe Fiedler, Thomas Langer
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引用次数: 101

Abstract

Mitochondria are essential metabolic hubs that dynamically adapt to physiological demands. More than 40 proteases residing in different compartments of mitochondria, termed mitoproteases, preserve mitochondrial proteostasis and are emerging as central regulators of mitochondrial plasticity. These multifaceted enzymes limit the accumulation of short-lived, regulatory proteins within mitochondria, modulate the activity of mitochondrial proteins by protein processing, and mediate the degradation of damaged proteins. Various signaling cascades coordinate the activity of mitoproteases to preserve mitochondrial homeostasis and ensure cell survival. Loss of mitoproteases severely impairs the functional integrity of mitochondria, is associated with aging, and causes pleiotropic diseases. Understanding the dual function of mitoproteases as regulatory and quality control enzymes will help unravel the role of mitochondrial plasticity in aging and disease.

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线粒体蛋白酶:线粒体可塑性的多方面调节因子。
线粒体是必要的代谢中心,动态适应生理需求。在线粒体的不同区室中,有40多种蛋白酶被称为有丝分裂蛋白酶,它们保持线粒体的蛋白质平衡,并成为线粒体可塑性的主要调节因子。这些多方面的酶限制线粒体内短寿命调节蛋白的积累,通过蛋白质加工调节线粒体蛋白的活性,并介导受损蛋白的降解。各种信号级联协调线粒体蛋白酶的活性,以保持线粒体稳态并确保细胞存活。线粒体蛋白酶的丧失严重损害线粒体的功能完整性,与衰老有关,并导致多种疾病。了解线粒体蛋白酶作为调节酶和质量控制酶的双重功能将有助于揭示线粒体可塑性在衰老和疾病中的作用。
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来源期刊
Annual review of biochemistry
Annual review of biochemistry 生物-生化与分子生物学
CiteScore
33.90
自引率
0.00%
发文量
31
期刊介绍: The Annual Review of Biochemistry, in publication since 1932, sets the standard for review articles in biological chemistry and molecular biology. Since its inception, these volumes have served as an indispensable resource for both the practicing biochemist and students of biochemistry.
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