Regulation and New Treatment Strategies in Breast Cancer.

Rosa-Maria Ferraiuolo, Kay-Uwe Wagner
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Abstract

Breast cancer classifications are based on the presence or absence of estrogen receptor and progesterone receptor along with the overexpression or amplification of the Her2 receptor. Although the overall 5-year survival rate of breast cancer patients has increased due to the use of targeted therapies, a subset of patients can acquire resistance over time or are unresponsive when presented in the clinic. Novel therapies focusing on molecular pathways and cell cycle regulation currently being used in the clinic may lead to increased response in this subset of patients.

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乳腺癌的调控和新的治疗策略。
乳腺癌的分类是基于雌激素受体和孕激素受体的存在与否以及Her2受体的过表达或扩增。虽然乳腺癌患者的总体5年生存率由于靶向治疗的使用而增加,但一小部分患者可能随着时间的推移产生耐药性,或者在临床上出现无反应。目前临床上使用的专注于分子途径和细胞周期调节的新疗法可能会增加这部分患者的反应。
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