Carbetapentane citrate.

Q1 Pharmacology, Toxicology and Pharmaceutics Profiles of drug substances, excipients, and related methodology Pub Date : 2020-01-01 Epub Date: 2019-12-05 DOI:10.1016/bs.podrm.2019.10.002
Ahmed S Abo Dena, Alaa M Ali, Ibrahim M El-Sherbiny
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Abstract

Carbetapentane citrate, a non-opioid centrally-acting antitussive drug, is a common treatment for cough associated with other diseases such as common cold and respiratory tract infections. Its mode of action is very close to that of atropine; since it acts at the level of the peripheral parasympathetic nerve endings. The drug reaches its maximum plasma concentration (Cmax) 2h after administration, and it has a plasma half-life of 2.3h in case of oral administration. Due to its clinical importance, there are many analytical methods in the literature for carbetapentane determination. In addition, it is crucial to collect its analytical results in a single chapter so as to allow researchers to easily interpret their experimental data. Here, we provide the analytical profile of carbetapentane citrate with a brief description/interpretation of each analysis.

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柠檬酸卡贝塔戊烷。
柠檬酸卡丁戊烷是一种非阿片类药物中枢作用止咳药,是治疗与普通感冒和呼吸道感染等其他疾病相关的咳嗽的常用药物。它的作用方式与阿托品非常接近;因为它作用于外周副交感神经末梢。给药后2h达到最大血药浓度(Cmax),口服给药的半衰期为2.3h。由于其在临床中的重要性,文献中有许多测定碳戊烷的分析方法。此外,它是至关重要的收集其分析结果在一个单一的章节,使研究人员可以很容易地解释他们的实验数据。在这里,我们提供了柠檬酸碳戊烷的分析概况,并对每个分析进行了简要的描述/解释。
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来源期刊
Profiles of drug substances, excipients, and related methodology
Profiles of drug substances, excipients, and related methodology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
13.10
自引率
0.00%
发文量
4
期刊最新文献
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