{"title":"The Impact of Comorbid Alzheimer's Disease in a Patient with Normal Pressure Hydrocephalus?","authors":"Halil Onder","doi":"10.12779/dnd.2020.19.1.31","DOIUrl":null,"url":null,"abstract":"I read with great interest the article by Kang et al.1 in which they describe a patient with normal pressure hydrocephalus (NPH) who had clinically worsened 9 years after shunt surgery and was evaluated as unresponsive to ventriculoperitoneal shunt (VP shunt) modification. Further investigation of 18F-florbetaben positron emission tomography showed extensively increased diffusion uptake supporting the diagnosis of Alzheimer's disease (AD). Based on this illustration, the authors discuss the importance of differentiating between NPH and AD to avoid disappointing results and remark AD as crucial comorbidity in NPH that can lead to shunt unresponsiveness.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/10/64/dnd-19-31.PMC7105716.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dementia and neurocognitive disorders","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12779/dnd.2020.19.1.31","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/2/28 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
I read with great interest the article by Kang et al.1 in which they describe a patient with normal pressure hydrocephalus (NPH) who had clinically worsened 9 years after shunt surgery and was evaluated as unresponsive to ventriculoperitoneal shunt (VP shunt) modification. Further investigation of 18F-florbetaben positron emission tomography showed extensively increased diffusion uptake supporting the diagnosis of Alzheimer's disease (AD). Based on this illustration, the authors discuss the importance of differentiating between NPH and AD to avoid disappointing results and remark AD as crucial comorbidity in NPH that can lead to shunt unresponsiveness.
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