Vascular Effects of Avocado Seed Glycosides during Diabetes-induced Endothelial Damage.

Q2 Medicine Cardiovascular and Hematological Disorders - Drug Targets Pub Date : 2020-01-01 DOI:10.2174/1871529X20666200510012012

Peter U Amadi, Emmanuel N Agomuo, Chiamaka Adumekwe

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Abstract

Background and objectives: The relationship between vascular damage and diabetes mellitus was exploited using avocado seed extracts. The purpose of the study was to understand the therapeutic relevance of glycosides compared to standard vascular and anti-diabetic drugs. Constituent Avocado Seed Glycosides (ASG) were analysed and administered to rats with Diabetes-Induced Vascular Damage (DIVD).

Methods: The rats were first administered with streptozotocin and screened after seven days for alterations in blood glucose, insulin, vascular cell adhesion molecule (VCAM-1), Von Willebrand factor (VWF), Renin-Angiotensin-Aldosterone System (RAS), eNOx, and endothelin-1 (ET-1). Only rats that satisfied these criteria were recruited and treated with either glibenclamide, met.su + losart, or 200 mg/kg body weight ASG for 28 days.

Results: There was an abundance of digitoxin (13.41 mg/100g), digoxin (17.98 mg/100g), avicularin (165.85 mg/100g), and hyperoside (282.51 mg/100g). ASG or met.su + losart exhibited slight modulatory properties on glucose homeostasis. Rats with DIVD showed elevated renin, angiotensin, VCAM-1 and Lp-PLA2 levels but slightly decreased with glibenclamide treatment and normalized with ASG or met.su + losart administration. All treatments normalized Hcy levels. DIVD caused the overproduction of CnT, LDH, Crt-K, LDL-c, TG, and TC and suppressed HDL-c but was completely normalized by the ASG. Water intake remained altered in treated rats.

Conclusion: The ASG had no relevant effect on glucose homeostasis during DIVD but showed significant vasoprotective properties.

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牛油果籽苷在糖尿病诱发内皮损伤过程中对血管的影响

背景和目的：利用鳄梨种子提取物研究了血管损伤与糖尿病之间的关系。研究的目的是了解苷类与标准血管和抗糖尿病药物相比的治疗相关性。研究分析了牛油果籽苷（ASG）的成分，并给糖尿病诱发血管损伤（DIVD）的大鼠用药：首先给大鼠注射链脲佐菌素，七天后检测血糖、胰岛素、血管细胞粘附分子（VCAM-1）、冯-威廉因子（VWF）、肾素-血管紧张素-醛固酮系统（RAS）、eNOx 和内皮素-1（ET-1）的变化。只有符合这些标准的大鼠才会被招募，并接受格列本脲、met.su + losart 或 200 毫克/千克体重的 ASG 治疗 28 天：结果：大鼠体内含有大量地高辛（13.41 毫克/100 克）、地高辛（17.98 毫克/100 克）、阿维菌素（165.85 毫克/100 克）和金丝桃苷（282.51 毫克/100 克）。ASG 或 met.su + losart 对糖稳态有轻微的调节作用。DIVD大鼠的肾素、血管紧张素、VCAM-1和Lp-PLA2水平升高，但在格列本脲治疗后略有下降，在服用ASG或met.su + losart后恢复正常。所有治疗均可使 Hcy 水平恢复正常。DIVD会导致CnT、LDH、Crt-K、LDL-c、TG和TC过度生成，并抑制HDL-c，但ASG可使其完全恢复正常。结论：ASG对DIVD期间的葡萄糖稳态没有相关影响，但具有显著的血管保护特性。

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来源期刊

Cardiovascular and Hematological Disorders - Drug Targets Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： Cardiovascular & Hematological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in cardiovascular and hematological disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in cardiovascular and hematological disorders. As the discovery, identification, characterization and validation of novel human drug targets for cardiovascular and hematological drug discovery continues to grow.