Applications of radiomics in precision diagnosis, prognostication and treatment planning of head and neck squamous cell carcinomas.

Cancers of the head & neck Pub Date : 2020-05-04 eCollection Date: 2020-01-01 DOI:10.1186/s41199-020-00053-7
Stefan P Haider, Barbara Burtness, Wendell G Yarbrough, Seyedmehdi Payabvash
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引用次数: 44

Abstract

Recent advancements in computational power, machine learning, and artificial intelligence technology have enabled automated evaluation of medical images to generate quantitative diagnostic and prognostic biomarkers. Such objective biomarkers are readily available and have the potential to improve personalized treatment, precision medicine, and patient selection for clinical trials. In this article, we explore the merits of the most recent addition to the "-omics" concept for the broader field of head and neck cancer - "Radiomics". This review discusses radiomics studies focused on (molecular) characterization, classification, prognostication and treatment guidance for head and neck squamous cell carcinomas (HNSCC). We review the underlying hypothesis, general concept and typical workflow of radiomic analysis, and elaborate on current and future challenges to be addressed before routine clinical application.

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放射组学在头颈部鳞状细胞癌精准诊断、预后及治疗计划中的应用。
计算能力、机器学习和人工智能技术的最新进展使医学图像的自动评估能够生成定量诊断和预后生物标志物。这些客观的生物标记物很容易获得,并且有可能改善个性化治疗、精准医疗和临床试验的患者选择。在这篇文章中,我们探讨了“-组学”概念的最新补充,为头颈部癌症的更广泛的领域-“放射组学”的优点。本文综述了放射组学在头颈部鳞状细胞癌(HNSCC)的分子特征、分类、预后和治疗指导方面的研究。我们回顾了放射组学分析的基本假设、一般概念和典型工作流程,并阐述了常规临床应用前需要解决的当前和未来挑战。
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