Circulating microRNAs: Next-generation Cancer Detection.

IF 1.1 Q4 MEDICINE, RESEARCH & EXPERIMENTAL KEIO JOURNAL OF MEDICINE Pub Date : 2020-12-25 Epub Date: 2020-05-13 DOI:10.2302/kjm.2019-0011-OA
Juntaro Matsuzaki, Takahiro Ochiya
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引用次数: 8

Abstract

Early detection of cancer is crucial for its ultimate control and the prevention of malignant progression. In Japan, a nationwide project was conducted between 2014 and 2019 to develop novel cancer detection tools using serum microRNAs (miRNAs). Using the National Cancer Center Biobank, we collected more than 10,000 serum samples from patients with malignant diseases, including rare cancers such as ovarian cancer, gliomas, and sarcomas. Subsequently, comprehensive miRNA microarray analyses were performed for all samples. This serum miRNA database provides insights regarding miRNA biomarker candidates for each cancer type. Here, we summarize the major achievements of this national project. Notably, although circulating miRNAs packaged in extracellular vesicles are thought to be a cell-to-cell communication tool, the functional characteristics of the miRNAs listed in the project are still unknown. We hope that our findings will help elucidate the biological functions of circulating miRNAs.

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循环microrna:下一代癌症检测。
癌症的早期发现对于最终控制和预防恶性进展至关重要。在日本,2014年至2019年期间开展了一项全国性项目,旨在开发利用血清微rna (miRNAs)的新型癌症检测工具。利用国家癌症中心生物样本库,我们收集了一万多例恶性疾病患者的血清样本,包括卵巢癌、胶质瘤和肉瘤等罕见癌症。随后,对所有样品进行全面的miRNA微阵列分析。该血清miRNA数据库提供了关于每种癌症类型的miRNA生物标志物候选物的见解。在此,我们对这项国家工程的主要成果进行总结。值得注意的是,尽管包装在细胞外囊泡中的循环mirna被认为是细胞间通信的工具,但该项目中列出的mirna的功能特征仍然未知。我们希望我们的发现将有助于阐明循环mirna的生物学功能。
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来源期刊
KEIO JOURNAL OF MEDICINE
KEIO JOURNAL OF MEDICINE MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
3.10
自引率
0.00%
发文量
23
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