Association of PAI-1 rs1799889 Polymorphism with Susceptibility to Ischemic Stroke: a Huge Meta-Analysis based on 44 Studies.

Q3 Medicine Acta medica (Hradec Kralove) Pub Date : 2020-01-01 DOI:10.14712/18059694.2020.13

Mohammadali Jafari, Mohammad Hossein Jarahzadeh, Seyed Alireza Dastgheib, Neda Seifi-Shalamzari, Ali Raee-Ezzabadi, Jalal Sadeghizadeh-Yazdi, Elahe Akbarian, Hossein Neamatzadeh

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引用次数: 11

Abstract

Background: the PAI-1 rs1799889 polymorphism has been reported to be associated with susceptibility to ischemic stroke. However, the results of previous studies have been inconsistent or controversial. Hence, we performed a systematic review and meta-analysis to evaluate the association of PAI-1 rs1799889 polymorphism with ischemic stroke risk.

Methods: A comprehensive literature search was performed on PubMed, Web of Science, Scopus, SciELO, CNKI, and CBD databases up to November 05, 2019. Pooled odds ratio (OR) with 95% confidence interval (CI) were used to access the strength of this association in fixed- or random-effects model.

Results: A total of 44 case-control studies with 8,620 cases and 10,260 controls were selected. Pooled data showed a significant association between PAI-1 rs1799889 polymorphism and ischemic stroke risk in the overall populations (GG vs. AA: OR = 0.791, 95% CI 0.633-0.988, p = 0.039; GA vs. AA: OR = 0.807, 95% CI 0.683-0.953, p = 0.012; and GG+GA vs. AA: OR = 0.795, 95% CI 0.637-0.993, p = 0.043). Subgroup analysis by ethnicity revealed a significant association in Asian and Mixed populations, but not in Caucasians. Moreover, stratified analysis by country of origin revealed an increased risk of ischemic stroke in Chinese populations, but not among Dutch (Netherlands) and Swedish.

Conclusions: This meta-analysis result suggested that PAI-1 rs1799889 polymorphism was associated with an increased risk of ischemic stroke, especially in Asian and Mixed populations.

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PAI-1 rs1799889多态性与缺血性卒中易感性的关联:一项基于44项研究的大型meta分析

背景:PAI-1 rs1799889多态性已被报道与缺血性卒中易感性相关。然而，以往的研究结果一直不一致或有争议。因此，我们进行了系统回顾和荟萃分析，以评估PAI-1 rs1799889多态性与缺血性卒中风险的关系。方法:检索截至2019年11月5日的PubMed、Web of Science、Scopus、SciELO、CNKI和CBD数据库。在固定效应或随机效应模型中，采用合并优势比(OR)和95%置信区间(CI)来评估这种关联的强度。结果:共纳入44项病例对照研究，共纳入病例8620例，对照10260例。汇总数据显示，PAI-1 rs1799889多态性与总体人群缺血性卒中风险之间存在显著相关性(GG vs. AA: OR = 0.791, 95% CI 0.633-0.988, p = 0.039;GA vs. AA: OR = 0.807, 95% CI 0.683-0.953, p = 0.012;GG+GA vs. AA: OR = 0.795, 95% CI 0.637 ~ 0.993, p = 0.043)。按种族划分的亚组分析显示，在亚洲和混血人群中有显著关联，但在白种人中没有。此外，按原籍国进行的分层分析显示，缺血性中风的风险在中国人群中增加，但在荷兰和瑞典人群中没有增加。结论:本荟萃分析结果表明PAI-1 rs1799889多态性与缺血性卒中风险增加有关，特别是在亚洲和混合人群中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta medica (Hradec Kralove) Medicine-Medicine (all)

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： Acta Medica (Hradec Králové) is a multidisciplinary medical journal published by the Faculty of Medicine in Hradec Králové - Karolinum Press, the publishing house of Charles University. The journal is peer-reviewed and published quarterly in both paper and electronic form. The language of Acta Medica is English. Offerings include review articles, original articles, brief communications, case reports, announcements and notices. The journal was founded in 1958 under the title "A Collection of Scientific Works of the Charles University Faculty of Medicine in Hradec Kralove."