The Impact of obesity and diabetes mellitus on pancreatic cancer: Molecular mechanisms and clinical perspectives.

IF 5.3 2区医学 Q1 Biochemistry, Genetics and Molecular Biology Journal of Cellular and Molecular Medicine Pub Date : 2020-07-01 Epub Date: 2020-05-26 DOI:10.1111/jcmm.15413

Bao Quoc Lam, Sushant K Shrivastava, Anju Shrivastava, Sharmila Shankar, Rakesh K Srivastava

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引用次数: 24

Abstract

The incidence of obesity and type 2 diabetes (T2DM) in the Western world has increased dramatically during the recent decades. According to the American Cancer Society, pancreatic cancer (PC) is the fourth leading cause of cancer-related death in the United States. The relationship among obesity, T2DM and PC is complex. Due to increase in obesity, diabetes, alcohol consumption and sedentary lifestyle, the mortality due to PC is expected to rise significantly by year 2040. The underlying mechanisms by which diabetes and obesity contribute to pancreatic tumorigenesis are not well understood. Furthermore, metabolism and microenvironment within the pancreas can also modulate pancreatic carcinogenesis. The risk of PC on a population level may be reduced by modifiable lifestyle risk factors. In this review, the interactions of diabetes and obesity to PC development were summarized, and novel strategies for the prevention and treatment of diabetes and PC were discussed.

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肥胖和糖尿病对胰腺癌的影响:分子机制和临床观点。

近几十年来，肥胖和2型糖尿病(T2DM)在西方世界的发病率急剧上升。据美国癌症协会称，胰腺癌(PC)是美国癌症相关死亡的第四大原因。肥胖、T2DM和PC之间的关系是复杂的。由于肥胖、糖尿病、酒精消费和久坐不动的生活方式的增加，预计到2040年，PC导致的死亡率将显著上升。糖尿病和肥胖导致胰腺肿瘤发生的潜在机制尚不清楚。此外，胰腺内的代谢和微环境也可以调节胰腺癌的发生。在人群水平上，PC的风险可以通过改变生活方式的风险因素来降低。本文就糖尿病和肥胖与PC发生的相互作用进行综述，并就糖尿病和PC的防治策略进行探讨。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cellular and Molecular Medicine 医学-细胞生物学

CiteScore

10.00

自引率

1.90%

发文量

496

审稿时长

28 weeks

期刊介绍： Bridging physiology and cellular medicine, and molecular biology and molecular therapeutics, Journal of Cellular and Molecular Medicine publishes basic research that furthers our understanding of the cellular and molecular mechanisms of disease and translational studies that convert this knowledge into therapeutic approaches.