The Association Between Comorbidity, Frailty, and Outdoor Mobility Loss Among Community-Dwelling Individuals 60 Years of Age and Above in Moscow.

IF 2.2 4区 医学 Q3 GERIATRICS & GERONTOLOGY Rejuvenation research Pub Date : 2021-04-01 Epub Date: 2020-07-14 DOI:10.1089/rej.2019.2289
Olga N Tkacheva, Nadezda K Runikhina, Liudmila I Merkusheva, Sergei N Lysenkov, Valentina S Ostapenko, Natalia V Sharashkina, Yan Press
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Abstract

To determine the prognostic value of frailty and comorbidity for outdoor mobility loss and mortality in the elderly. The retrospective study was conducted among outpatients aged ≥60 years. Patients with ≥3 chronic illnesses were treated by doctors who had undergone a 72-hour geriatric training. The outdoor low-mobility group comprised patients who failed to visit a doctor because of decreased outdoor mobility during the 3-year follow-up period. The outdoor high-mobility group comprised participants with no outdoor mobility loss. 5678 patients with a mean age of 71.0 ± 0.1 years were included in the study. The risk of outdoor mobility loss rose by 4% per year with men developing it 30% more than women. The effect of frailty was of particular importance because it increased the risk of developing outdoor mobility loss by 70%. Comorbidity was not associated with a higher risk of outdoor mobility loss, but the investigators did not take into account all possible illnesses, or the severity of disease. The loss of outdoor mobility was associated with increase in mortality. Early detection of frailty can help predict outdoor mobility loss and could reduce mortality among older people.

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莫斯科60岁及以上社区居民共病、虚弱和户外活动能力丧失之间的关系
确定老年人户外活动能力丧失和死亡率的虚弱和合并症的预后价值。回顾性研究对象为年龄≥60岁的门诊患者。患有≥3种慢性疾病的患者由接受过72小时老年医学培训的医生治疗。户外活动能力低组包括在3年随访期间因户外活动能力减少而未能去看医生的患者。户外高活动能力组由没有户外活动能力丧失的参与者组成。研究共纳入5678例患者,平均年龄为71.0±0.1岁。户外活动能力丧失的风险每年增加4%,其中男性比女性多30%。虚弱的影响尤其重要,因为它使户外活动能力丧失的风险增加了70%。合并症与户外活动能力丧失的高风险无关,但研究人员没有考虑到所有可能的疾病或疾病的严重程度。户外活动能力的丧失与死亡率的增加有关。早期发现虚弱可以帮助预测户外活动能力的丧失,并可以降低老年人的死亡率。
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来源期刊
Rejuvenation research
Rejuvenation research 医学-老年医学
CiteScore
4.50
自引率
0.00%
发文量
41
审稿时长
3 months
期刊介绍: Rejuvenation Research publishes cutting-edge, peer-reviewed research on rejuvenation therapies in the laboratory and the clinic. The Journal focuses on key explorations and advances that may ultimately contribute to slowing or reversing the aging process, and covers topics such as cardiovascular aging, DNA damage and repair, cloning, and cell immortalization and senescence. Rejuvenation Research coverage includes: Cell immortalization and senescence Pluripotent stem cells DNA damage/repair Gene targeting, gene therapy, and genomics Growth factors and nutrient supply/sensing Immunosenescence Comparative biology of aging Tissue engineering Late-life pathologies (cardiovascular, neurodegenerative and others) Public policy and social context.
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