Efficacy of Thiamine in the Treatment of Postcardiac Arrest Patients: A Randomized Controlled Study.

IF 1.8 Q3 CRITICAL CARE MEDICINE Critical Care Research and Practice Pub Date : 2020-06-08 eCollection Date: 2020-01-01 DOI:10.1155/2020/2981079

Suntornwit Pradita-Ukrit, Veerapong Vattanavanit

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引用次数: 5

Abstract

Background: Thiamine administration has been shown to improve survival in a postcardiac arrest animal study. We aimed to evaluate the efficacy of thiamine in comatose out-of-hospital cardiac arrest (OHCA) patients following return of spontaneous circulation.

Methods: A randomized, double-blinded, placebo-controlled study was conducted. Thirty-seven OHCA patients were randomly assigned to receive either thiamine 100 mg every 8 hours or a placebo. The primary outcome was 28-day all-cause mortality.

Results: Over the course of 2 years, 37 patients were randomized to either receive thiamine (n = 20) or a placebo (n = 17). The primary outcome was not different between the groups: 10/20 (50%) in the thiamine group vs. 8/17 (47.1%) in the placebo group (P=0.93 by the log-rank test). There were no significant differences in secondary outcomes between the groups (good neurological outcome, lactate level, and S100B level).

Conclusions: In this study, there were no significant differences in survival outcome. Further studies with a larger population are necessary to confirm these results.

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硫胺素治疗心脏骤停患者的疗效:一项随机对照研究。

背景:在一项心脏骤停后的动物研究中，硫胺素已被证明可以提高生存率。我们的目的是评估硫胺素在院外心脏骤停(OHCA)昏迷患者恢复自然循环后的疗效。方法:采用随机、双盲、安慰剂对照研究。37名OHCA患者被随机分配接受每8小时100毫克的硫胺素或安慰剂。主要终点为28天全因死亡率。结果:在2年的研究过程中，37名患者被随机分配接受硫胺素治疗(n = 20)或安慰剂治疗(n = 17)。两组间的主要结局无差异:硫胺素组为10/20(50%)，安慰剂组为8/17 (47.1%)(log-rank检验P=0.93)。两组间的次要结局(良好的神经预后、乳酸水平和S100B水平)无显著差异。结论:在本研究中，两组患者的生存结局无显著差异。需要对更大的人群进行进一步的研究来证实这些结果。

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