Antihyperglycemic Potential of Matricaria pubescens (Desf.) Schultz. in Streptozotocin-induced Diabetic Rats.

Q2 Medicine Cardiovascular and Hematological Disorders - Drug Targets Pub Date : 2020-01-01 DOI:10.2174/1871529X20666200630112610

Ayoub Amssayef, Mohammed Ajebli, Mohamed Eddouks

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引用次数: 1

Abstract

Aims: The study aimed to investigate the antihyperglycemic activity of Matricaria pubescens.

Background: Matricaria pubescens (Def). Shultz (Asteraceae) is commonly used traditionally for the treatment of diabetes in Morocco.

Objective: The present investigation aimed to assess the antihyperglycemic and antioxidant effects of the aqueous extract of the aerial part of Matricaria pubescens (M. pubescens).

Methods: The effect of a single and repeated oral administration of the aqueous extract of aerial part of M. pubescens (AEAPMP) at a dose of 40 mg/kg on glucose was examined in normal and streptozotocin-induced diabetic rats. Additionally, histopathological examination of the pancreas and liver was carried out according to the Hematoxylin-Eosin method. The antioxidant activity was performed using the DPPH assay.

Results: The results showed that the aqueous extract of M. pubescens (AEAPMP) exhibited a significant lowering activity on blood glucose levels in STZ-induced diabetic rats. In addition, AEAPMP ameliorated the histopathological tissues of the liver and pancreas. Furthermore, in vitro antioxidant activity of AEAPMP has been shown.

Conclusion: In conclusion, this study demonstrates that M. pubescens possesses a beneficial effect against hyperglycemia associated with diabetes.

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毛蕊草的抗高血糖潜能舒尔茨。链脲佐菌素诱导的糖尿病大鼠。

目的:研究毛蕊草的降血糖作用。背景:母羊属植物(Def)。Shultz(菊科)在摩洛哥传统上通常用于治疗糖尿病。目的:研究短毛母草(M. pubescens)地上部水提物的降血糖和抗氧化作用。方法:分别以40 mg/kg剂量单次和多次口服短毛藤气部水提物(AEAPMP)对正常和链脲佐菌素诱导的糖尿病大鼠血糖的影响。胰、肝按苏木精-伊红法行组织病理学检查。采用DPPH法测定其抗氧化活性。结果:毛茛水提物(AEAPMP)对stz诱导的糖尿病大鼠血糖水平有明显的降低作用。此外，AEAPMP改善了肝脏和胰腺的组织病理组织。此外，AEAPMP还具有体外抗氧化活性。结论:综上所述，本研究证明毛蕊支原体对糖尿病相关高血糖具有有益作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular and Hematological Disorders - Drug Targets Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.90

自引率

0.00%

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期刊介绍： Cardiovascular & Hematological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in cardiovascular and hematological disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in cardiovascular and hematological disorders. As the discovery, identification, characterization and validation of novel human drug targets for cardiovascular and hematological drug discovery continues to grow.