Investigation and Management of Bone Mineral Density Following Hematopoietic Cell Transplantation: A Survey of Current Practice by the Transplant Complications Working Party of the European Society for Blood and Marrow Transplantation

Nina Salooja , Hildegaard Greinix , Tapani Ruutu , Steffie van der Werf , Anja van Biezen , Anita Lawitschka , Grzegorz Basak , Rafael Duarte
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Abstract

Reduced bone mineral density (BMD) is a well-recognized complication of hematopoietic cell transplantation (HCT), with significant drops in BMD occurring within the first 12 months after HCT. Guidance on identifying and managing this complication is available in several published guidelines. In this study, we investigated current practices in the investigation and management of low BMD in centers registered with the European Society for Blood and Marrow Transplantation (EBMT). A questionnaire about bone health was sent to all registered centers, and responses were received from 99 centers in 25 countries (52%) currently registered with the EBMT. Our data highlight considerable heterogeneity in practices across European centers in relation to investigations, management, and use of guidelines. Our data demonstrate the need for better dissemination and implementation of existing guidelines and also for the development of multidisciplinary guidelines with input from all relevant stakeholders.

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造血细胞移植后骨密度的调查和管理:欧洲血液和骨髓移植学会移植并发症工作组对当前实践的调查
骨矿物质密度(BMD)降低是造血细胞移植(HCT)的一个公认的并发症,骨密度在HCT后的头12个月内显著下降。在一些已出版的指南中提供了关于识别和处理这种并发症的指导。在这项研究中,我们调查了目前在欧洲血液和骨髓移植协会(EBMT)注册的中心调查和管理低骨密度的做法。向所有注册中心发送了一份关于骨骼健康的问卷,并收到了来自25个国家99个中心(52%)目前在EBMT注册的回复。我们的数据突出了欧洲各中心在调查、管理和使用指南方面的实践存在相当大的异质性。我们的数据表明,需要更好地传播和实施现有指南,也需要在所有相关利益相关者的投入下制定多学科指南。
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来源期刊
CiteScore
6.60
自引率
0.00%
发文量
1061
审稿时长
3-6 weeks
期刊介绍: Biology of Blood and Marrow Transplantation publishes original research reports, reviews, editorials, commentaries, letters to the editor, and hypotheses and is the official publication of the American Society for Transplantation and Cellular Therapy. The journal focuses on current technology and knowledge in the interdisciplinary field of hematopoetic stem cell transplantation.
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