Comparison of whole-cell versus acellular pertussis vaccine effectiveness in school clusters of pertussis, France, 2013

IF 5 Q3 Medicine Medecine et maladies infectieuses Pub Date : 2020-10-01 DOI:10.1016/j.medmal.2020.07.004

E. Belchior , S. Guillot , I. Poujol , A. Thabuis , L. Chouin , M. Martel , E. Delisle , C. Six , N. Guiso , D. Lévy-Bruhl

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引用次数: 7

Abstract

Objectives and method

We conducted a prospective study in 2013 to compare the whole-cell versus acellular pertussis vaccines effectiveness and duration of protection, following the occurrence of pertussis clusters.

Results

During seven school outbreaks, we identified 102 clinical pertussis cases, including 10 cases biologically confirmed by Bordetella pertussis specific PCR, among a cohort of 305 children in 2nd to 6th grade. The risk of pertussis when vaccinated with an acellular vaccine alone was 1.6 (RR = 1.6; 95% CI = 1.1–2.5) times higher than when vaccinated with a whole-cell vaccine or using a combined schedule.

Conclusions

The limited duration of protection conferred by the acellular vaccine reinforces the 2013 introduction of the pertussis booster at six years old.

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全细胞与非细胞百日咳疫苗在学校聚集性百日咳中的有效性比较，法国，2013

目的和方法我们在2013年进行了一项前瞻性研究，比较全细胞和非细胞百日咳疫苗在百日咳聚集性发生后的有效性和保护时间。结果在7次学校暴发中，我们在305名2至6年级儿童中发现102例临床百日咳病例，其中10例经百日咳博德泰拉特异性PCR生物学证实。单用无细胞疫苗接种百日咳的风险为1.6 (RR = 1.6;95% CI = 1.1-2.5)比接种全细胞疫苗或使用联合接种计划时高。结论:无细胞疫苗提供的有限保护时间加强了2013年在6岁时引入百日咳加强剂。

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来源期刊

Medecine et maladies infectieuses 医学-传染病学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

10.7 weeks

期刊介绍： L''organe d''expression de la Société de Pathologie Infectieuse de Langue Française (SPILF). Médecine et Maladies Infectieuses is the official publication of the Société de Pathologie Infectieuse de Langue Française (SPILF). Médecine et Maladies Infectieuses is indexed in the major databases: Medline, Web of Science/Clarivate and Scopus. The journal publishes scientific /research articles, general reviews, short communications and letters, in both English and French. The journal welcomes submissions on the various aspects of infectious pathologies and pathogenic agents. Médecine et Maladies Infectieuses focuses on clinical therapeutics, nosocomial infections, biology, prevention, as well as epidemiology and therapeutics.