Challenges for management of post kala-azar dermal leishmaniasis and future directions.

IF 3.1 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Research and Reports in Tropical Medicine Pub Date : 2014-11-14 eCollection Date: 2014-01-01 DOI:10.2147/RRTM.S35707
Dinesh Mondal, Shinjiro Hamano, Golam Hasnain, Abhay R Satoskar
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引用次数: 5

Abstract

Post kala-azar dermal leishmaniasis (PKDL) is a skin complication resulting from infection with Leishmania donovani (LD) parasite. It mostly affects individuals who have previously suffered from visceral leishmaniasis (VL) caused by LD. In some cases, PKDL develops among people infected with LD, but do not show any symptoms of VL. Clinical presentation includes hypopigmented macules/papules/nodules or polymorphic lesions (combination of two or more lesions). Except for skin lesions, PKDL patients are generally healthy and usually do not seek medical care. These patients play an important role in interepidemic transmission of the infection and subsequent VL outbreak. Therefore, proper diagnosis and treatment of PKDL patients is important for the control of VL in endemic countries, especially in the Indian subcontinent where VL is anthroponotic. Here, we report the challenges in the estimation of PKDL burden, its diagnosis, and treatment, and suggest possible solutions based on recent literature, reports, published manuals, and web-based information.

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黑热病后皮肤利什曼病管理的挑战和未来方向。
黑热病后皮肤利什曼病(PKDL)是由多诺瓦利什曼原虫(LD)寄生虫感染引起的皮肤并发症。它主要影响以前患有由LD引起的内脏利什曼病(VL)的个体。在某些情况下,PKDL在感染LD的人群中发展,但没有任何VL的症状。临床表现包括低色素斑/丘疹/结节或多形态病变(两种或两种以上病变的合并)。除皮肤病变外,PKDL患者一般健康,通常不求医。这些患者在感染的流行间传播和随后的VL暴发中发挥重要作用。因此,正确诊断和治疗PKDL患者对于在流行国家控制VL非常重要,特别是在VL由人源性传播的印度次大陆。在这里,我们报告了PKDL负担的估计、诊断和治疗方面的挑战,并根据最近的文献、报告、出版的手册和基于网络的信息提出了可能的解决方案。
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来源期刊
Research and Reports in Tropical Medicine
Research and Reports in Tropical Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
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发文量
7
审稿时长
16 weeks
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