Alexander W. Hartland , Kar H. Teoh , Mustafa S. Rashid
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引用次数: 0
Abstract
Introduction
Blood loss is an important consideration in all types of shoulder surgery. Excessive bleeding is associated with increased morbidity. Tranexamic acid (TXA) is an antifibrinolytic agent. It has been demonstrated to be effective in reducing blood loss across multiple surgical specialties. The aim of this systematic review and meta-analysis is to review the literature evaluating clinical outcomes associated with the use of TXA in shoulder surgery.
Methods
The study protocol was designed and registered prospectively on PROSPERO (International prospective register for systematic reviews). Literature search will include the MEDLINE, EMBASE, PsycINFO, and Cochrane Library databases. Randomised controlled trials (RCTs) evaluating the use of TXA against placebo, in all types of shoulder surgery, will be included. Our primary outcome is total blood loss (ml). Secondary outcomes include patient-reported outcome measures (PROMs), adverse events, and number of blood transfusions required. Risk of bias will be assessed within each study using The Cochrane Risk of Bias Tool 2.0 and the Jadad score. Inconsistency and bias across included studies will be assessed statistically. Data from comparable outcomes will be pooled and analysed quantitatively or descriptively as appropriate.
Ethics and dissemination
No ethical clearances required for this study. This systematic review and meta-analysis will be published in a peer-reviewed journal. It will be presented a various national and international conferences.
在所有类型的肩部手术中,失血都是一个重要的考虑因素。出血过多与发病率增加有关。氨甲环酸是一种抗纤溶剂。它已被证明是有效的减少失血在多个外科专业。本系统综述和荟萃分析的目的是回顾评估与肩关节手术中使用TXA相关的临床结果的文献。方法设计研究方案,并在PROSPERO (International prospective register for systematic reviews)上前瞻性注册。文献检索将包括MEDLINE、EMBASE、PsycINFO和Cochrane图书馆数据库。将包括评估在所有类型的肩部手术中使用TXA与安慰剂的随机对照试验(rct)。我们的主要终点是总失血量(ml)。次要结局包括患者报告的结局指标(PROMs)、不良事件和所需输血次数。将使用Cochrane Risk of bias Tool 2.0和Jadad评分评估每项研究的偏倚风险。纳入研究的不一致性和偏倚将进行统计学评估。可比较结果的数据将进行汇总,并酌情进行定量或描述性分析。伦理与传播本研究不需要伦理许可。该系统综述和荟萃分析将发表在同行评议的期刊上。它将在各种国内和国际会议上展出。
期刊介绍:
IJS Protocols is the first peer-reviewed, international, open access journal seeking to publish research protocols across across the full breadth of the surgical field. We are aim to provide rapid submission to decision times whilst maintaining a high quality peer-review process.