Picornavirus Cellular Remodeling: Doubling Down in Response to Viral-Induced Inflammation.

IF 3.1 Q2 MICROBIOLOGY Current Clinical Microbiology Reports Pub Date : 2020-06-01 Epub Date: 2020-04-17 DOI:10.1007/s40588-020-00138-4

Alexis Bouin, Bert L Semler

引用次数: 0

Abstract

Purpose of review: To highlight recent findings on how picornavirus infections of the airways and cardiac tissues impact cellular inflammation and remodeling events.

Recent findings: Recent published work has revealed that although many picornavirus infections appear to be initially asymptomatic, there are significant disease sequelae that result from chronic or persistent infections and the long-term, pathogenic effects on host tissues.

Summary: Because many acute picornavirus infections are asymptomatic, it is difficult to diagnose these pathologies at the early stages of disease. As a result, we must rely on preventative measures (i.e., vaccination) or discover novel treatments to reverse tissue damage and remodeling in affected individuals. Both of these strategies will require a comprehensive knowledge of virus-and cell-specific replication determinants and how these processes induce pathogenic effects in infected cells and tissues.

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皮卡病毒细胞重塑：加倍努力应对病毒引发的炎症

综述的目的：重点介绍有关呼吸道和心脏组织的短小病毒感染如何影响细胞炎症和重塑事件的最新研究成果：摘要：由于许多急性皮卡病毒感染没有症状，因此很难在疾病的早期阶段诊断出这些病症。因此，我们必须依靠预防措施（如接种疫苗）或发现新的治疗方法来逆转受影响个体的组织损伤和重塑。这两种策略都需要全面了解病毒和细胞特异性复制决定因素，以及这些过程如何在受感染细胞和组织中诱发致病效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Clinical Microbiology Reports MICROBIOLOGY-

CiteScore

7.50

自引率

1.90%

发文量

期刊介绍： Current Clinical Microbiology Reports commissions expert reviews from leading scientists at the forefront of research in microbiology. The journal covers this broad field by dividing it into four key main areas of study: virology, bacteriology, parasitology, and mycology. Within each of the four sections, experts from around the world address important aspects of clinical microbiology such as immunology, diagnostics, therapeutics, antibiotics and antibiotic resistance, and vaccines. Some of the world’s foremost authorities in the field of microbiology serve as section editors and editorial board members. Section editors select topics for which leading researchers are invited to contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, which are highlighted in annotated reference lists. These timely reviews of the literature examine the latest scientific discoveries and controversies as they emerge and are indispensable to both researchers and clinicians. The editorial board, composed of more than 20 internationally diverse members, reviews the annual table of contents, ensures that topics address all aspects of emerging research, and where applicable suggests topics of critical importance to various countries/regions.

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