Major CYP450 Polymorphism among Saudi Patients.

Drug metabolism letters Pub Date : 2021-01-01 DOI:10.2174/1872312814666200722122232

Ahmad A Almeman

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引用次数: 3

Abstract

Background: Cytochrome P450 (CYP) contributes to a huge collection of medicinal products' Phase I metabolization. We aimed to summarize and investigate the current evidence regarding the frequency of CYP2D6, CYP2C9, CYP2C19, and MDR1 in Saudi Arabia.

Methods: A computerized search in four databases was done using the relevant keywords. The screening process was done in two steps; title and abstract screening and full-text screening. Data of demographic and characteristics of included studies and patients were extracted and tabulated.

Results: Ten studies were eligible for our criteria and were included in this systematic review. The age of participants ranged between 17-65 years. Only two subjects showed PM phenotype of CYP2C19 in the Saudi population. The most frequent alleles were CYP2C19*1 (62.9%), CYP2C19*2 (11.2%-32%), and CYP2C19*17 (25.7%). The CYP2C19_m1 was observed in 97 cases of extensive metabolizing (EM) phenotype CYP2C19. Concerning the CYP2C9, the most frequent alleles were CYP2C9*1 and CYP2C9*2, and the most frequent genotype was CYP2C9*1*1. The CYP2D6*41 allele and C1236T MDR1 were the most frequent allele in this population.

Conclusion: The current evidence suggests that Saudi resembled European in the frequency of CYP2C19, Caucasians in both the incidence of CYP2C9 and CYP2C19_m1, and the absence of CYP2C19_m2. The CYP2D6*41 allele frequency in Saudi is relatively high. We recommend further research to evaluate the basic and clinical relevance of gene polymorphism in such ethnicity.

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沙特患者CYP450基因多态性研究

背景:细胞色素P450 (CYP)在药物I期代谢中起着重要作用。我们的目的是总结和调查沙特阿拉伯CYP2D6、CYP2C9、CYP2C19和MDR1频率的现有证据。方法:利用相关关键词在4个数据库中进行计算机检索。筛选过程分为两个步骤;标题和摘要筛选和全文筛选。提取纳入研究和患者的人口学和特征数据并制成表格。结果:10项研究符合我们的标准，并被纳入本系统评价。参与者的年龄在17-65岁之间。在沙特人群中，只有两名受试者显示CYP2C19的PM表型。最常见的等位基因为CYP2C19*1(62.9%)、CYP2C19*2(11.2% ~ 32%)和CYP2C19*17(25.7%)。在97例广泛代谢(EM)型CYP2C19患者中观察到CYP2C19m1。CYP2C9中，最常见的等位基因为CYP2C9*1和CYP2C9*2，最常见的基因型为CYP2C9*1*1。CYP2D6*41等位基因和C1236T MDR1等位基因是该人群中最常见的等位基因。结论:目前的证据表明，沙特人CYP2C19的频率与欧洲人相似，CYP2C9和CYP2C19m1的发病率与高加索人相似，CYP2C19m2的缺失与欧洲人相似。沙特CYP2D6*41等位基因频率较高。我们建议进一步研究，以评估基因多态性在这一种族的基础和临床相关性。

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Drug metabolism letters Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

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期刊介绍： Drug Metabolism Letters publishes letters and research articles on major advances in all areas of drug metabolism and disposition. The emphasis is on publishing quality papers very rapidly by taking full advantage of the Internet technology both for the submission and review of manuscripts. The journal covers the following areas: In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites.