Elena Britti, Fabien Delaspre, Jordi Tamarit, Joaquim Ros
{"title":"Mitochondrial calcium signalling and neurodegenerative diseases.","authors":"Elena Britti, Fabien Delaspre, Jordi Tamarit, Joaquim Ros","doi":"10.1042/NS20180061","DOIUrl":null,"url":null,"abstract":"<p><p>Calcium is utilised by cells in signalling and in regulating ATP production; it also contributes to cell survival and, when concentrations are unbalanced, triggers pathways for cell death. Mitochondria contribute to calcium buffering, meaning that mitochondrial calcium uptake and release is intimately related to cytosolic calcium concentrations. This review focuses on the proteins contributing to mitochondrial calcium homoeostasis, the roles of the mitochondrial permeability transition pore (MPTP) and mitochondrial calcium-activated proteins, and their relevance in neurodegenerative pathologies. It also covers alterations to calcium homoeostasis in Friedreich ataxia (FA).</p>","PeriodicalId":74287,"journal":{"name":"Neuronal signaling","volume":"2 4","pages":"NS20180061"},"PeriodicalIF":0.0000,"publicationDate":"2018-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/NS20180061","citationCount":"33","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuronal signaling","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1042/NS20180061","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/12/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"Neuroscience","Score":null,"Total":0}
引用次数: 33
Abstract
Calcium is utilised by cells in signalling and in regulating ATP production; it also contributes to cell survival and, when concentrations are unbalanced, triggers pathways for cell death. Mitochondria contribute to calcium buffering, meaning that mitochondrial calcium uptake and release is intimately related to cytosolic calcium concentrations. This review focuses on the proteins contributing to mitochondrial calcium homoeostasis, the roles of the mitochondrial permeability transition pore (MPTP) and mitochondrial calcium-activated proteins, and their relevance in neurodegenerative pathologies. It also covers alterations to calcium homoeostasis in Friedreich ataxia (FA).
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