Potential Drugs and Remedies for the Treatment of COVID-19: a Critical Review.

IF 3.7 3区 生物学 Q1 BIOCHEMICAL RESEARCH METHODS Biological Procedures Online Pub Date : 2020-07-23 eCollection Date: 2020-01-01 DOI:10.1186/s12575-020-00129-1
Fatemeh Barati, Mahdi Pouresmaieli, Elena Ekrami, Sahar Asghari, Farzad Ramezani Ziarani, Matin Mamoudifard
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引用次数: 25

Abstract

Abstract: COVID-19 disease with a high rate of contagious and highly nonspecific symptoms, is an infectious disease caused by a newly discovered coronavirus. Most people who fall sick with COVID-19 will experience mild to moderate symptoms such as respiratory symptoms, cough, dyspnea, fever, and viral pneumonia and recover without any special cure. However, some others need special and emergency treatment to get rid of this widespread disease. Till now, there are numbers of proposed novel compounds as well as standards therapeutics agent existed for other conditions seems to have efficacy against the 2019-nCoV. Some which are being tested for MERS-CoV and SARS-CoV are validated that could be also efficient against this new coronavirus. However, there are currently no effective specific antivirals or drug combinations introduced for 2019-nCoV specifically that be supported by high-level evidence. The main purpose of this paper is to review typical and ongoing treatments for coronavirus disease including home remedies, herbal medicine, chemical drugs, plasma therapy, and also vaccinies. In this regards, famous herbal medicines and common chemical drugs which are routinely to be prescribed for patients are introduced. Moreover, a section is assigned to the drug interactions and some outdated drugs which have been proved to be inefficient. We hope that this work could pave the way for researchers to develop faster and more reliable methods for earlier treatment of patients and rescue more people.

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治疗新冠肺炎的潜在药物和补救措施:一项关键审查。
摘要:新冠肺炎是由一种新发现的冠状病毒引起的传染性疾病,具有较高的传染性和高度非特异性症状。大多数新冠肺炎患者会出现轻度至中度症状,如呼吸道症状、咳嗽、呼吸困难、发烧和病毒性肺炎,并在没有任何特殊治疗的情况下康复。然而,其他一些人需要特殊和紧急治疗来摆脱这种广泛存在的疾病。到目前为止,有许多新提出的化合物以及针对其他疾病的标准治疗剂似乎对2019-nCoV有效。一些正在进行MERS-CoV和SARS-CoV测试的病毒也被证实对这种新型冠状病毒有效。然而,目前还没有针对2019-nCoV推出的有效的特异性抗病毒药物或药物组合得到高水平证据的支持。本文的主要目的是综述冠状病毒疾病的典型和正在进行的治疗方法,包括家庭疗法、草药、化学药物、血浆疗法和疫苗。在这方面,介绍了为患者开具常规处方的著名草药和常见化学药物。此外,还为药物相互作用和一些过时的药物分配了一个部分,这些药物已被证明是低效的。我们希望这项工作能为研究人员开发更快、更可靠的方法来早期治疗患者和拯救更多的人铺平道路。图形摘要:
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来源期刊
Biological Procedures Online
Biological Procedures Online 生物-生化研究方法
CiteScore
10.50
自引率
0.00%
发文量
16
审稿时长
>12 weeks
期刊介绍: iological Procedures Online publishes articles that improve access to techniques and methods in the medical and biological sciences. We are also interested in short but important research discoveries, such as new animal disease models. Topics of interest include, but are not limited to: Reports of new research techniques and applications of existing techniques Technical analyses of research techniques and published reports Validity analyses of research methods and approaches to judging the validity of research reports Application of common research methods Reviews of existing techniques Novel/important product information Biological Procedures Online places emphasis on multidisciplinary approaches that integrate methodologies from medicine, biology, chemistry, imaging, engineering, bioinformatics, computer science, and systems analysis.
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