{"title":"The Covid-19 Global Pandemic: A Natural Experiment in the Making.","authors":"David M Mutch","doi":"10.1159/000510217","DOIUrl":null,"url":null,"abstract":"[...]these natural experiments happen whether people want them to or not! Even after strict travel restrictions were implemented, the virus spread rapidly across the USA and phylogenetic analyses have proved useful to clarify the importance of domestic transmission [5]. [...]recent bioinformatic analyses of complete viral genomes suggest increasing diversification of SARS-CoV-2 strains [6]. Furthermore, a study in patients with lupus showed that the ACE2 gene is under epigenetic control, where hypomethylation was associated with increased ACE2 gene expression [10]. [...]it is plausible that lifestyle factors that regulate the epigenome may also alter a person’s risk of infection. [...]it will be important to follow babies born at different points during the pandemic, as well as young children, to determine whether COVID-19-induced lifestyle changes in parents have any long-lasting ramifications on offspring as they age.","PeriodicalId":18030,"journal":{"name":"Lifestyle Genomics","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000510217","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lifestyle Genomics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000510217","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/8/7 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 6
Abstract
[...]these natural experiments happen whether people want them to or not! Even after strict travel restrictions were implemented, the virus spread rapidly across the USA and phylogenetic analyses have proved useful to clarify the importance of domestic transmission [5]. [...]recent bioinformatic analyses of complete viral genomes suggest increasing diversification of SARS-CoV-2 strains [6]. Furthermore, a study in patients with lupus showed that the ACE2 gene is under epigenetic control, where hypomethylation was associated with increased ACE2 gene expression [10]. [...]it is plausible that lifestyle factors that regulate the epigenome may also alter a person’s risk of infection. [...]it will be important to follow babies born at different points during the pandemic, as well as young children, to determine whether COVID-19-induced lifestyle changes in parents have any long-lasting ramifications on offspring as they age.
期刊介绍：
Lifestyle Genomics aims to provide a forum for highlighting new advances in the broad area of lifestyle-gene interactions and their influence on health and disease. The journal welcomes novel contributions that investigate how genetics may influence a person’s response to lifestyle factors, such as diet and nutrition, natural health products, physical activity, and sleep, amongst others. Additionally, contributions examining how lifestyle factors influence the expression/abundance of genes, proteins and metabolites in cell and animal models as well as in humans are also of interest. The journal will publish high-quality original research papers, brief research communications, reviews outlining timely advances in the field, and brief research methods pertaining to lifestyle genomics. It will also include a unique section under the heading “Market Place” presenting articles of companies active in the area of lifestyle genomics. Research articles will undergo rigorous scientific as well as statistical/bioinformatic review to ensure excellence.
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