Cytomegalovirus Infection Is a Risk Factor in Gastrointestinal Cancer: A Cross-Sectional and Meta-Analysis Study.

IF 3.2 4区医学 Q3 VIROLOGY Intervirology Pub Date : 2020-01-01 Epub Date: 2020-08-07 DOI:10.1159/000506683

Ya-Li Lv, Fei-Fei Han, Zhuo-Ling An, Yangjie Jia, Ling-Ling Xuan, Li-Li Gong, Wen Zhang, Lu-Lu Ren, Song Yang, He Liu, Li-Hong Liu

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引用次数: 14

Abstract

Background: This study was planned to investigate the association betweenhuman cytomegalovirus (HCMV) infection and gastrointestinal cancer (GIC) risk, by undertaking a meta-analysis and case-control cross-sectional study.

Summary: A cross-sectional study analysis of 160 GIC patients and 100 control subjects indicated significantly higher HCMV prevalence in GIC patients based on the HCMV IgM test. However, a similar analysis based on an IgG test revealed no significant relationship. Further meta-analysis of 11 studies, including 1,044 patients and 991 healthy subjects, displayed HCMV infection as an important risk factor for not only colorectal cancer occurrence and development based on a HCMV DNA test, but also for GIC based on a HCMV IgM test. However, the IgG test again displayed no significant relationship between HCMV infection and GIC occurrence. Key Message: Overall, our study revealed that HCMV infection is associated with an increased GIC risk. However, additional studies are warranted to elucidate the molecular mechanism underlying this association.

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巨细胞病毒感染是胃肠道癌症的危险因素:一项横断面和荟萃分析研究。

背景:本研究计划通过荟萃分析和病例对照横断面研究来调查人类巨细胞病毒(HCMV)感染与胃肠道癌(GIC)风险之间的关系。摘要:一项对160名GIC患者和100名对照患者的横断面研究分析表明，基于HCMV IgM测试，GIC患者的HCMV患病率明显更高。然而，基于IgG测试的类似分析显示没有显著关系。对包括1044名患者和991名健康受试者在内的11项研究的进一步荟萃分析显示，HCMV感染不仅是基于HCMV DNA检测的结直肠癌发生和发展的重要危险因素，也是基于HCMV IgM检测的GIC的重要危险因素。然而，IgG检测再次显示HCMV感染与GIC发生无显著关系。关键信息:总的来说，我们的研究显示HCMV感染与GIC风险增加有关。然而，需要进一步的研究来阐明这种关联的分子机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Intervirology 医学-病毒学

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Intervirology'' covers progress in both basic and clinical virus research, and aims to provide a forum for the various disciplines within virology. Issues publishing original papers alternate with thematic issues, focusing on clearly defined topics. This thematic concentration serves to make timely reviews, research reports and controversy easily accessible to both specialists in the field and those who want to keep track of the latest developments outside their own area of interest. In addition to original papers, regular issues publish short communications and letters to the editor to provide readers with a forum for the exchange of ideas and comments. The scope encompasses work on the molecular biology of human and animal viruses, including genome organization and regulation, and the structure and function of viral proteins. The pathogenesis, immunology, diagnosis, epidemiology, prophylaxis and therapy of viral diseases are considered.