β-1,3-glucan Attenuated Chronic Unpredictable Mild Stress-induced Cognitive Impairment in Rodents via Normalizing Corticosterone Levels.

Q3 Psychology Central nervous system agents in medicinal chemistry Pub Date : 2020-01-01 DOI:10.2174/1871524920666200810142359

Saniya H Khan, Sheraz Khan, Narmeen Hashim, Inamullah Khan

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引用次数: 3

Abstract

Background: Chronic stress elevates the cortisol beyond normal levels, which affects cognition including learning & memory. This injurious effect is primarily mediated via over excitation of metabotropic glucocorticoid receptors (mGR).

Methods: The present study was aimed to appraise the neuroprotective effects of naturally occurring molecule β-1,3-glucan by interfering with stress-cortisol-mGR axis. Our data of virtual screening (in silico) exhibited the promising interactions of β-glucan with the mGR. Therefore, the study was extended to evaluate its efficacy (2.5, 5 and 10 mg/kg/ i.p) in an animal model of chronic unpredictable mild stress (CUMS, 28 days) induced memory impairment.

Results: Results of the current study revealed the β-glucan provided dose dependent protection against deleterious effects of stress on learning and memory associated parameters observed in Morris water maze (MWM) task. At higher tested doses, it has also significantly antagonized the stress induced weight loss and corticosterone elevation.

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β-1,3-葡聚糖通过使皮质酮水平正常化来减轻啮齿动物慢性不可预测的轻度应激性认知障碍。

背景:慢性应激会使皮质醇升高到正常水平以上，从而影响包括学习和记忆在内的认知。这种有害作用主要通过代谢糖皮质激素受体(mGR)的过度兴奋介导。方法:本研究旨在通过干扰应激-皮质醇- mgr轴，评价天然分子β-1,3-葡聚糖的神经保护作用。我们的虚拟筛选数据(在硅)显示β-葡聚糖与mGR有希望的相互作用。因此，本研究扩展到评估其(2.5、5和10 mg/kg/ i.p)对慢性不可预测轻度应激(CUMS, 28天)诱导的记忆障碍动物模型的疗效。结果:在Morris水迷宫(MWM)实验中，β-葡聚糖对应激对大鼠学习记忆相关参数的影响具有剂量依赖性。在更高的测试剂量下，它也显著拮抗应激引起的体重减轻和皮质酮升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Central nervous system agents in medicinal chemistry Psychology-Neuropsychology and Physiological Psychology

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.