Association of MC4R (rs17782313) with diabetes and cardiovascular disease in Korean men and women.

4区医学 Q4 Medicine BMC Medical Genetics Pub Date : 2020-08-17 DOI:10.1186/s12881-020-01100-3

Jae Woong Sull, Gitae Kim, Sun Ha Jee

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引用次数: 9

Abstract

Background: Diabetes is mostly assessed by the fasting glucose level. Several studies reported that serum fasting glucose levels and cardiovascular disease are associated with MC4R.

Methods: A total of 4294 subjects participated in this study. There were 1810 subjects with cardiovascular disease among the 4294 subjects. We used multivariate linear regression models and multiple logistic regression analysis.

Results: Individuals with the TC/CC genotype had a 1.29-fold higher risk of diabetes than did those with the TT genotype when adjusting for age, sex, and BMI (OR, 1.29; 95% CI, 1.04-1.60). For healthy subjects, the association was significant in women (OR, 1.99; 95% CI, 1.01-3.93). Men with the TC/CC genotype had a 1.21-fold higher risk of cardiovascular disease than did those with the TT genotype when adjusting for age, sex, and BMI (OR, 1.21; 95% CI, 1.04-1.41). The relationship between MC4R and cardiovascular disease was stronger in lean men (OR, 1.40; 95% CI, 1.12-1.74, p = 0.0028) than in overweight men.

Conclusions: This study suggests that the rs17782313 SNP in MC4R is related to diabetes and the SNP is also associated with cardiovascular disease in lean men.

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MC4R (rs17782313)与韩国男性和女性糖尿病和心血管疾病的关系

背景:糖尿病主要通过空腹血糖水平来评估。一些研究报道了血清空腹血糖水平和心血管疾病与MC4R相关。方法:共4294名受试者参与本研究。4294名受试者中有1810名患有心血管疾病。我们采用多元线性回归模型和多元逻辑回归分析。结果:在调整年龄、性别和BMI后，TC/CC基因型个体患糖尿病的风险是TT基因型个体的1.29倍(OR, 1.29;95% ci, 1.04-1.60)。对于健康受试者，女性的相关性显著(OR, 1.99;95% ci, 1.01-3.93)。在调整年龄、性别和BMI后，TC/CC基因型男性患心血管疾病的风险比TT基因型男性高1.21倍(OR, 1.21;95% ci, 1.04-1.41)。MC4R与心血管疾病的关系在瘦男性中更强(OR, 1.40;95% CI, 1.12-1.74, p = 0.0028)高于超重男性。结论:本研究提示MC4R中rs17782313 SNP与糖尿病相关，且该SNP与瘦男性心血管疾病相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Medical Genetics 医学-遗传学

自引率

0.00%

发文量

审稿时长

12 months

期刊介绍： BMC Medical Genetics is an open access journal publishing original peer-reviewed research articles in the effects of genetic variation in individuals, families and among populations in relation to human health and disease. Note: BMC Medical Genetics is now closed. This journal has merged with BMC Medical Genomics, a broad-scope, open access community journal for all medical genetics and genomics research.