Common Sources of Inflammation and Their Impact on Hematopoietic Stem Cell Biology.

IF 2.3 Q4 CELL & TISSUE ENGINEERING Current Stem Cell Reports Pub Date : 2020-01-01 Epub Date: 2020-08-17 DOI:10.1007/s40778-020-00177-z

Daniel Hormaechea-Agulla, Duy T Le, Katherine Y King

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Abstract

Purpose of review: Inflammatory signals have emerged as critical regulators of hematopoietic stem cell (HSC) function. Specifically, HSCs are highly responsive to acute changes in systemic inflammation and this influences not only their division rate but also their lineage fate. Identifying how inflammation regulates HSCs and shapes the blood system is crucial to understanding the mechanisms underpinning these processes, as well as potential links between them.

Recent findings: A widening array of physiologic and pathologic processes involving heightened inflammation are now recognized to critically affect HSC biology and blood lineage production. Conditions documented to affect HSC function include not only acute and chronic infections but also autoinflammatory conditions, irradiation injury, and physiologic states such as aging and obesity.

Summary: Recognizing the contexts during which inflammation affects primitive hematopoiesis is essential to improving our understanding of HSC biology and informing new therapeutic interventions against maladaptive hematopoiesis that occurs during inflammatory diseases, infections, and cancer-related disorders.

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炎症的常见来源及其对造血干细胞生物学的影响。

综述的目的：炎症信号已成为造血干细胞功能的关键调节因子。具体而言，造血干细胞对全身炎症的急性变化反应强烈，这不仅影响其分裂率，还影响其血统命运。确定炎症如何调节造血干细胞和塑造血液系统，对于了解这些过程的基本机制以及它们之间的潜在联系至关重要：现在人们认识到，涉及炎症加剧的一系列生理和病理过程会严重影响造血干细胞生物学和血型生成。据记载，影响造血干细胞功能的情况不仅包括急性和慢性感染，还包括自身炎症、辐照损伤以及衰老和肥胖等生理状态：认识到炎症影响原始造血的背景，对于增进我们对造血干细胞生物学的了解，以及为针对炎症性疾病、感染和癌症相关疾病中出现的不适应性造血的新治疗干预提供信息至关重要。

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来源期刊

Current Stem Cell Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

0.00%

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期刊介绍： The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of stem cell research, therapy, ethics, commercialization, and policy. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.