Venom peptides in association with standard drugs: a novel strategy for combating antibiotic resistance - an overview.

IF 1.8 3区 医学 Q4 TOXICOLOGY Journal of Venomous Animals and Toxins Including Tropical Diseases Pub Date : 2020-08-10 eCollection Date: 2020-01-01 DOI:10.1590/1678-9199-JVATITD-2020-0001
Ashish K Lamiyan, Ramkesh Dalal, Neelima R Kumar
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引用次数: 2

Abstract

Development of antibiotic resistance that leads to resurgence of bacterial infections poses a threat to disease-free existence for humankind and is a challenge for the welfare of the society at large. Despite research efforts directed towards treatment of pathogens, antibiotics within new improved classes have not emerged for years, a fact largely attributable to the pharmacological necessities compelling drug development. Recent reversion to the use of natural products alone or in combination with standard drugs has opened up new vistas for alternative therapeutics. The success of this strategy is evident in the sudden interest in plant extracts as additives/synergists for treatment of maladies caused by drug-resistant bacterial strains. Animal venoms have long fascinated scientists as sources of pharmacologically active components that can be exploited for the treatment of specific ailments and should be promoted further to clinical trials. In the present review, we outline the scope and possible methods for the applications of animal venoms in combination with commercial antibiotics to offer a better treatment approach against antibiotic-resistant infections.

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与标准药物相关的毒液肽:一种对抗抗生素耐药性的新策略-综述。
抗生素耐药性的发展导致细菌感染的死灰复燃,对人类的无病生存构成威胁,对整个社会的福利构成挑战。尽管针对治疗病原体的研究努力,在新的改良类抗生素没有出现多年,这一事实在很大程度上可归因于药理学的必要性迫使药物开发。最近对天然产品单独使用或与标准药物联合使用的回归为替代疗法开辟了新的前景。这一策略的成功体现在人们突然对植物提取物作为添加剂/增效剂用于治疗由耐药菌株引起的疾病产生兴趣。长期以来,动物毒液作为一种可用于治疗特定疾病的药理活性成分的来源一直吸引着科学家,应该进一步推广到临床试验中。在本文中,我们概述了动物毒液与商业抗生素联合应用的范围和可能的方法,以提供更好的治疗抗生素耐药感染的方法。
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来源期刊
CiteScore
4.80
自引率
8.30%
发文量
39
审稿时长
6-12 weeks
期刊介绍: Journal of Venomous Animals and Toxins including Tropical Diseases (JVATiTD) is a non-commercial academic open access publication dedicated to research on all aspects of toxinology, venomous animals and tropical diseases. Its interdisciplinary content includes original scientific articles covering research on toxins derived from animals, plants and microorganisms. Topics of interest include, but are not limited to:systematics and morphology of venomous animals;physiology, biochemistry, pharmacology and immunology of toxins;epidemiology, clinical aspects and treatment of envenoming by different animals, plants and microorganisms;development and evaluation of antivenoms and toxin-derivative products;epidemiology, clinical aspects and treatment of tropical diseases (caused by virus, bacteria, algae, fungi and parasites) including the neglected tropical diseases (NTDs) defined by the World Health Organization.
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