[Safety and acceptability of the 52 mg levonorgestrel-releasing intrauterine system in women with abnormal uterine bleeding in an ambulatory care center in Bogotá, Colombia, 2012-2016].

Patricia Sandoval-Vivas
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Abstract

Objective: To describe safety and acceptability with the use of the 52-mg levonorgestrel-releasing intrauterine system in women with abnormal uterine bleeding.

Methods: Retrospective cohort of women 18 years of age and older diagnosed with abnormal uterine bleeding, ultrasound-reported uterine length between 6 and 10 cm and uniform endometrial cavity in its entire length, regardless of structural abnormality, who received treatment with 52-mg levonorgestrel-releasing intrauterine system between 2012 and 2016. Non-probabilistic convenience sampling was carried out. Sociodemographic and clinical baseline variables were measured, as well as patient perception of bleeding and the frequency of failure, amenorrhea, need for hysterectomy and adverse events, over a 12-month follow-up period. Descriptive statistics were applied.

Results: Overall, 200 patients were assessed. A subjective perception of improvement in terms of bleeding volume and frequency of leave of absence or visits to the emergency department was found; 90 % of the patients had amenorrhea, and 6 % experienced adverse events.

Conclusions: The 52-mg levonorgestrel-releasing intrauterine system is a safe option for the management of abnormal uterine bleeding in women with normal uterine size and no submucosal endometrial abnormalities. Local randomized studies are required to assess effectiveness and efficiency in comparison with other management options.

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[2012-2016年哥伦比亚波哥大一家门诊中心52 mg左炔诺孕酮释放宫内系统在异常子宫出血患者中的安全性和可接受性]。
目的:探讨52 mg左炔诺孕酮释放宫内系统用于子宫异常出血患者的安全性和可接受性。方法:回顾性队列研究2012 - 2016年接受52 mg左炔诺孕酮释放宫内系统治疗的18岁及以上诊断为子宫异常出血、超声报告子宫长度在6 - 10 cm之间、子宫腔全长均匀且无结构异常的女性。采用非概率方便抽样。在12个月的随访期间,测量了社会人口学和临床基线变量,以及患者对出血的感觉和失败的频率、闭经、子宫切除术的需要和不良事件。采用描述性统计。结果:总共评估了200例患者。发现,在出血量和请假或到急诊科就诊的频率方面,主观感觉有所改善;90%的患者闭经,6%的患者出现不良事件。结论:52 mg左炔诺孕酮释放宫腔系统是子宫大小正常、无粘膜下子宫内膜异常的妇女治疗子宫异常出血的安全选择。需要进行局部随机研究,以评估与其他管理方案相比的有效性和效率。
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来源期刊
Revista Colombiana de Obstetricia y Ginecologia
Revista Colombiana de Obstetricia y Ginecologia Medicine-Obstetrics and Gynecology
CiteScore
1.00
自引率
0.00%
发文量
21
审稿时长
20 weeks
期刊介绍: The Revista Colombiana de Obstetricia y Ginecología was founded in January 1949. It is the Federación Colombiana de Asociaciones de Obstetricia y Ginecología"s official periodic publication (formerly known as the Sociedad Colombiana de Obstetricia y Ginecología). It is published quarterly and the following abbreviation should be used when citing the journal: Rev. Colomb. Obstet. Ginecol. The publication is authorized by Mingobierno resolution 218/1950.
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