Engineered Biomimetic Neural Stem Cell Niche.

IF 2.3 Q4 CELL & TISSUE ENGINEERING Current Stem Cell Reports Pub Date : 2019-01-01 Epub Date: 2019-05-20 DOI:10.1007/s40778-019-00161-2

Rita Matta, Anjelica L Gonzalez

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Abstract

Purpose of review: Neural stem cells (NSCs) have the potential to proliferate and differentiate into functional neurons, heightening their potential use for therapeutic applications. This review explores bioengineered systems which recapitulate NSC niche cell-cell and cell-matrix interactions.

Recent findings: Delivery of NSCs to the cytotoxic injured brain is limited by low cell survival rates post-transplantation and poor maintenance of native niche bioactive components. The use of biomaterial platforms can mimic in vivo the environment of the two germinal areas of the adult brain in which NSCs thrive. An environmental mimic that includes extracellular proteins and moieties, along with appropriate biomechanical cues has recently demonstrated promising results in enhancing neurogenesis, aiding the production of a bioengineered niche.

Summary: Biocomposition, biomechanics, and biostructure can be manipulated through engineered platforms to re-create the biofunctionality of an NSC niche. Upon transplantation and delivery with biomimetic scaffolds, NSCs show potential to promote functional recovery and rebuild neural circuitry post neurological trauma.

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工程仿生神经干细胞。

综述目的：神经干细胞（NSCs）具有增殖和分化为功能性神经元的潜力，提高了其治疗应用的潜在用途。这篇综述探讨了再现神经干细胞龛细胞-细胞和细胞-基质相互作用的生物工程系统：向细胞毒性损伤的大脑输送 NSCs 受到移植后细胞存活率低和原生龛生物活性成分维持不良的限制。使用生物材料平台可以在体内模拟成体大脑两个发芽区的环境，NSCs就在这两个发芽区茁壮成长。包括细胞外蛋白质和分子以及适当的生物力学线索在内的环境模拟物最近在增强神经发生方面取得了可喜的成果，有助于生物工程龛的产生。摘要：生物构成、生物力学和生物结构可通过工程平台进行操作，以重新创建 NSC 龛的生物功能。在使用仿生支架进行移植和输送后，NSCs 显示出促进功能恢复和重建神经创伤后神经回路的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Stem Cell Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of stem cell research, therapy, ethics, commercialization, and policy. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.