Genetic Variants in Host Protein Disulfide Isomerase 2 (PDIA2) are Associated with Susceptibility to Chlamydia Trachomatis Infection.

Journal of the Association of Genetic Technologists Pub Date : 2020-01-01

Christopher Zysk, Steven Williams, Itzel Chavarria, Hailey Wilson, Adedayo Balogun, Emily Jacobs, Rachel Kaminski, Baru-Ta Foma, Jack Johnson, Wesley Lux, Kristyn McCoy, Stephen Morales, Gina Sanchez, Paul Grubb, Melanie Littlejohn, Ryan Mize, Jorge Moreno, Caryn Pirtle, Ericka C Hendrix, Katie M Bennett

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Abstract

Objectives: Objective: Host genetics can influence susceptibility to Chlamydia trachomatis infection. This study examined two genetic variants in human protein disulfide isomerase A2 (PDIA2), a member of a family of protein chaperones that participate in the chlamydial life cycle. Methods: A total of 278 male and female subjects, positive or negative for C. trachomatis infection, were genotyped for PDIA2 polymorphisms (rs400037 and rs419949) using real-time PCR and pyrosequencing. Results: There was a significant odds ratio of 8.21 (95% CI: 1.77-38.16) for rs400037 and 9.89 (95% CI: 1.19-82.10) for rs419949, for the AA genotypes. Conclusion: This indicates that individuals with the PDIA2 AA genotypes have significantly increased susceptibility to C. trachomatis infection as compared to the other PDIA2 genotypes (GG, GA). This correlation may be explained by an interactive role of host protein disulfide isomerases in the attachment and entry of C. trachomatis into cells.

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宿主蛋白二硫异构酶2 (PDIA2)的遗传变异与沙眼衣原体感染的易感性相关

目的:目的:宿主遗传可影响沙眼衣原体感染的易感性。这项研究检测了人类蛋白二硫异构酶A2 (PDIA2)的两种遗传变异，PDIA2是参与衣原体生命周期的蛋白伴侣家族的成员。方法:采用实时荧光定量PCR和焦磷酸测序技术，对沙眼衣原体感染阳性或阴性的278名男女受试者进行PDIA2多态性(rs400037和rs419949)基因分型。结果:AA基因型rs400037的优势比为8.21 (95% CI: 1.77 ~ 38.16)， rs419949的优势比为9.89 (95% CI: 1.19 ~ 82.10)。结论:与其他PDIA2基因型相比，PDIA2 AA基因型个体对沙眼衣原体感染的易感性显著增加(GG, GA)。这种相关性可以用宿主蛋白二硫异构酶在沙眼衣原体附着和进入细胞中的相互作用来解释。

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Journal of the Association of Genetic Technologists

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