Melanoma in pregnancy: certainties unborn.

IF 1 Q4 ONCOLOGY Melanoma Management Pub Date : 2020-07-30 DOI:10.2217/mmt-2020-0007

Enrico Zelin, Claudio Conforti, Roberta Giuffrida, Teresa Deinlein, Nicola di Meo, Iris Zalaudek

引用次数: 0

Abstract

Melanoma diagnosed during childbearing period or up to 1 year after delivery is defined as pregnancy-associated melanoma (PAM). There is some evidence that PAM has worse prognosis if compared with melanoma in nonpregnant women, although literature is still inconclusive. Many biological mechanisms could explain this behavior, such as hormonal and immune status, increased lymphangiogenesis but also delay in diagnostic and therapeutic management. If PAM is suspected, a prompt excisional biopsy under local anesthesia can be performed regardless of the gestational period. Conversely, additional staging procedures (such as sentinel lymph node biopsy or imaging) and systemic therapy are still debatable during pregnancy. A multidisciplinary tailored approach should be preferred, together with exhaustive counseling of the mother.

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妊娠期黑色素瘤：不确定因素。

在育龄期或产后一年内确诊的黑色素瘤被定义为妊娠相关黑色素瘤（PAM）。有证据表明，与非妊娠期妇女的黑色素瘤相比，妊娠相关性黑色素瘤的预后较差，但目前尚无定论。许多生物学机制可以解释这种情况，如荷尔蒙和免疫状态、淋巴管生成增加以及诊断和治疗管理的延迟。如果怀疑是 PAM，无论妊娠期长短，都可以在局部麻醉下及时进行切除活检。相反，在妊娠期进行额外的分期手术（如前哨淋巴结活检或成像）和全身治疗仍有争议。应首选多学科的定制方法，并对母亲进行详尽的咨询。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Melanoma Management ONCOLOGY-

CiteScore

5.10

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Skin cancer is on the rise. According to the World Health Organization, 132,000 melanoma skin cancers occur globally each year. While early-stage melanoma is usually relatively easy to treat, once disease spreads prognosis worsens considerably. Therefore, research into combating advanced-stage melanoma is a high priority. New and emerging therapies, such as monoclonal antibodies, B-RAF and KIT inhibitors, antiangiogenic agents and novel chemotherapy approaches hold promise for prolonging survival, but the search for a cure is ongoing. Melanoma Management publishes high-quality peer-reviewed articles on all aspects of melanoma, from prevention to diagnosis and from treatment of early-stage disease to late-stage melanoma and metastasis. The journal presents the latest research findings in melanoma research and treatment, together with authoritative reviews, cutting-edge editorials and perspectives that highlight hot topics and controversy in the field. Independent drug evaluations assess newly approved medications and their role in clinical practice. Key topics covered include: Risk factors, prevention and sun safety education Diagnosis, staging and grading Surgical excision of melanoma lesions Sentinel lymph node biopsy Biological therapies, including immunotherapy and vaccination Novel chemotherapy options Treatment of metastasis Prevention of recurrence Patient care and quality of life.